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首页> 外文期刊>Nanotechnology >Cyclodextrin nanoaggregates and their assembly with protein: a spectroscopic investigation
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Cyclodextrin nanoaggregates and their assembly with protein: a spectroscopic investigation

机译：环糊精纳米聚集体及其与蛋白质的组装：光谱研究

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摘要

Light scattering and time-resolved fluorescence spectroscopy results showed that specially designed amphiphilic cyclodextrins are able to bind a specific protein, PA-I lectin. When containing a galactosyl group, the self-assembled cyclodextrins interact with the protein affecting the dynamical properties of the system and the fluorescence lifetimes ( as well as the fluorescence anisotropy) of the protein itself. The self-assembled cyclodextrins containing a glucosyl group, on the other hand, do not induce any change in these measured quantities, suggesting no interaction with protein. This binding capability of galactosyl-modified cyclodextrins offers perspectives on exploiting self-assembled supramolecular structures as nano-carriers to deliver drugs to target tissues.
机译：光散射和时间分辨荧光光谱结果表明，经过特殊设计的两亲环糊精能够结合特定的蛋白质PA-1凝集素。当含有半乳糖基时，自组装的环糊精会与蛋白质相互作用，从而影响系统的动力学特性以及蛋白质本身的荧光寿命（以及荧光各向异性）。另一方面，含有葡萄糖基的自组装环糊精不会引起这些测量量的任何变化，表明与蛋白质没有相互作用。半乳糖基修饰的环糊精的这种结合能力为利用自组装超分子结构作为纳米载体将药物递送至靶组织提供了前景。

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