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首页> 外文期刊>Nanotechnology >Physical characterization of neurocatheter performance in a brain phantom gelatin with nanoscale porosity: steady-state and oscillatory flows
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Physical characterization of neurocatheter performance in a brain phantom gelatin with nanoscale porosity: steady-state and oscillatory flows

机译：具有纳米级孔隙的脑部幻影明胶中神经导管性能的物理表征：稳态和振荡流

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An agarose gelatin having nanoscale transport properties similar to those of in vivo mammalian brain was employed as a surrogate for living brain tissue in the evaluation of infusion therapy protocols and neurocatheters to be used in the treatment of brain tumours. The catheters under study were a polyimide tube of 950 mum outer diameter (OD) and 750 mum inner diameter (ID), and a silicone tube of 2.5 mm OD and 1.25 mm ID. From the pressure profiles that were measured during infusions of a solution of Bromphenol Blue dye into this gel, we infer that forces on the order of 0.1 fN were driving the solute molecules through the approx= 200 nm intramatrix voids in the gel at rates of approx= 10 mum s~(-1), which is within a factor of 5 of the value derived from the time rate of change of the volume of distribution of the infusate. In some of the infusions, a column of trapped air was left purposely in the catheter prior to delivery of dye into the gel in order to mimic the clinical situation where the neurosurgeon must keep the catheter unprimed because of the need to use a stylet to guide it into the brain. (In those cases, the catheter is attached to the infusion pump only following withdrawal of the stylet, and there is thus a column of air inside the catheter.) In our series of such 'unprimed infusions', an oscillatory behaviour in the pressure profiles was observed, with a centre frequency of approx= 35 mHz. Surface tension effects in the resulting air bubbles within the gel likely limited to < 3 nm the range of pore sizes into which flows could be coupled in that case. Circumstances associated with backflow of the dye along the catheter insertion path are also discussed.
机译：在评估输液治疗方案和用于治疗脑瘤的神经导管时，采用了具有与体内哺乳动物脑相似的纳米级传输特性的琼脂糖明胶作为活体脑组织的替代物。所研究的导管是外径为950毫米（OD）和内径为750毫米（ID）的聚酰亚胺管，外径为2.5毫米，内径为1.25毫米的硅胶管。从将溴酚蓝染料溶液注入该凝胶过程中测得的压力分布，我们推断出，以0.1 fN的力将溶质分子以大约200 nm的速率驱动通过凝胶中大约200 nm的基质内空隙= 10 um s〜（-1），在从输注液分配量的时间变化率得出的值的5倍之内。在某些输液中，在将染料输送到凝胶中之前，故意在导管中留出一列残留的空气，以模仿神经外科医生由于需要使用管心针进行引导而必须保持导管未灌注的临床情况。它进入大脑。 （在那些情况下，仅在抽出探针后，导管才连接到输液泵，因此导管内有一列空气。）在我们的这种“未灌注输液”系列中，压力曲线中的振荡行为观察到中心频率约为35 mHz。在这种情况下，凝胶中所产生的气泡中的表面张力效应可能限于<3 nm，在该孔径范围内，流体可能会进入其中。还讨论了与染料沿导管插入路径回流相关的情况。

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