...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nanotechnology >Polymeric worm micelles as nano-carriers for drug delivery
【24h】

Polymeric worm micelles as nano-carriers for drug delivery

机译：聚合蠕虫胶束作为药物递送的纳米载体

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Nanoscale carriers of active compounds, especially drugs, need not be spherical in shape. Worm micelles as blends of degradable polylactic acid (PLA) and inert block copolymer amphiphiles were prepared for controlled release and initial study of carrier transport through nano-porous media. The loading capacity of a typical hydrophobic drug, Triamterene, and the release of hydrophobic dyes were evaluated together with morphological changes of the micelles. Degradation of PLA by hydrolysis led to the self-shortening of worms and a clear transition towards spherical micelles, correlating with the release of hydrophobic dyes. Perhaps equally important for application is the flexibility of worm micelles, which we show allows them to penetrate nanoporous gels where 100 nm sized vesicles cannot enter. Such gels have served as tissue models, and so the results here collectively suggest a new class of hydrophobic drug nano-carriers that are capable of tissue permeation as well as controlled release.
机译：活性化合物，尤其是药物的纳米级载体不必是球形的。制备了可降解聚乳酸（PLA）和惰性嵌段共聚物两亲物共混物的蠕虫胶束，用于控制释放和通过纳米孔介质进行载体运输的初步研究。评价了典型疏水性药物Triamterene的负载量和疏水性染料的释放，以及胶束的形态变化。水解降解PLA会导致蠕虫自我缩短，并向球形胶束清晰过渡，这与疏水性染料的释放有关。也许对应用同样重要的是蠕虫胶束的柔韧性，我们证明了它可以使它们穿透纳米多孔凝胶，而100 nm大小的囊泡则无法进入。这样的凝胶已经用作组织模型，因此这里的结果共同表明一类新型的疏水性药物纳米载体，能够实现组织渗透和控释。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号