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The effect of polymer coatings on proton transverse relaxivities of aqueous suspensions of magnetic nanoparticles

机译：聚合物涂层对磁性纳米粒子水悬浮液质子横向弛豫的影响

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摘要

Iron oxide magnetic nanoparticles are good candidates for magnetic resonance imaging (MRI) contrast agents due to their high magnetic susceptibilities. Here we investigate 19 polyether-coated magnetite nanoparticle systems comprising three series. All systems were synthesized from the same batch of magnetite nanoparticles. A different polyether was used for each series. Each series comprised systems with systematically varied polyether loadings per particle. A highly significant (p < 0.0001) linear correlation (r = 0.956) was found between the proton relaxivity and the intensity-weighted average diameter measured by dynamic light scattering in the 19 particle systems studied. The intensity-weighted average diameter measured by dynamic light scattering is sensitive to small number fractions of larger particles/ aggregates. We conclude that the primary effect leading to differences in proton relaxivity between systems arises from the small degree of aggregation within the samples, which appears to be determined by the nature of the polymer and, for one system, the degree of polymer loading of the particles. For the polyether coatings used in this study, any changes in relaxivity from differences in water exclusion or diffusion rates caused by the polymer are minor in comparison with the changes in relaxivity resulting from variations in the degree of aggregation.
机译：氧化铁磁性纳米粒子由于其高磁化率而成为磁共振成像（MRI）造影剂的良好候选者。在这里，我们研究了包括三个系列的19个聚醚涂层磁铁矿纳米粒子系统。所有系统均由同一批磁铁矿纳米颗粒合成。每个系列使用不同的聚醚。每个系列均包含每个粒子的聚醚负载量会系统变化的系统。在所研究的19个粒子系统中，质子弛豫率与通过动态光散射测得的强度加权平均直径之间存在高度显着的（p <0.0001）线性相关（r = 0.956）。通过动态光散射测量的强度加权平均直径对较大颗粒/聚集体的少量分数敏感。我们得出结论，导致系统之间质子弛豫差异的主要影响是由样品内的小聚集度引起的，这似乎取决于聚合物的性质，对于一个系统，颗粒的聚合物负载程度。对于本研究中使用的聚醚涂料，由聚合物引起的吸水率或扩散速率差异引起的弛豫度变化与凝集度变化引起的弛豫度变化相比均较小。

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