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首页> 外文期刊>Nanotechnology >Minimal-invasive magnetic heating of tumors does not alter intra-tumoral nanoparticle accumulation, allowing for repeated therapy sessions: An in vivo study in mice
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Minimal-invasive magnetic heating of tumors does not alter intra-tumoral nanoparticle accumulation, allowing for repeated therapy sessions: An in vivo study in mice

机译：肿瘤的微创磁加热不会改变肿瘤内纳米颗粒的积聚，从而允许重复治疗：小鼠体内研究

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Localized magnetic heating treatments (hyperthermia, thermal ablation) using superparamagnetic iron oxide nanoparticles (MNPs) continue to be an active area of cancer research. For generating the appropriate heat to sufficiently target cell destruction, adequate MNP concentrations need to be accumulated into tumors. Furthermore, the knowledge of MNP bio-distribution after application and additionally after heating is significant, firstly because of the possibility of repeated heating treatments if MNPs remain at the target region and secondly to study potential adverse effects dealing with MNP dilution from the target region over time. In this context, little is known about the behavior of MNPs after intra-tumoral application and magnetic heating. Therefore, the present invivo study on the bio-distribution of intra-tumorally injected MNPs in mice focused on MNP long term monitoring of pre and post therapy over seven days using multi-channel magnetorelaxometry (MRX). Subsequently, single-channel MRX was adopted to study the bio-distribution of MNPs in internal organs and tumors of sacrificed animals. We found no distinct change of total MNP amounts invivo during long term monitoring. Most of the MNP amounts remained in the tumors; only a few MNPs were detected in liver and spleen and less than 1% of totally injected MNPs were excreted. Apparently, the application of magnetic heating and the induction of apoptosis did not affect MNP accumulation. Our results indicate that MNP mainly remained within the injection side after magnetic heating over a seven-days-observation and therefore not affecting healthy tissue. As a consequence, localized magnetic heating therapy of tumors might be applied periodically for a better therapeutic outcome.
机译：使用超顺磁性氧化铁纳米颗粒（MNP）进行局部磁加热治疗（体温过高，热消融）仍然是癌症研究的活跃领域。为了产生适当的热量以充分靶向细胞破坏，需要在肿瘤中积累足够的MNP浓度。此外，应用后以及加热后对MNP生物分布的了解非常重要，首先是因为如果MNP保留在目标区域，则可能会重复进行加热处理，其次是研究从目标区域稀释MNP的潜在不利影响。时间。在这种情况下，关于肿瘤内应用和磁加热后MNPs的行为知之甚少。因此，本体内研究小鼠体内肿瘤内注射的MNPs的生物分布的研究集中在MNP长期监测治疗前和治疗后7天的多通道磁弹性法（MRX）。随后，采用单通道MRX研究了MNP在被处死动物的内脏器官和肿瘤中的生物分布。在长期监测中，我们发现体内总MNP量没有明显变化。 MNP的大部分保留在肿瘤中。在肝脏和脾脏中仅检测到少量MNP，而仅注射的MNP中只有不到1％被排出。显然，磁加热的应用和细胞凋亡的诱导并不影响MNP的积累。我们的结果表明，在经过7天的观察后，磁加热后MNP主要保留在注射侧，因此不影响健康组织。结果，可以定期应用肿瘤的局部磁加热疗法以获得更好的治疗效果。

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