Pathogenetic mechanisms in thyroid follicular-cell neoplasia.

Kondo T; Ezzat S; Asa SL

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Pathogenetic mechanisms in thyroid follicular-cell neoplasia.

机译：甲状腺滤泡细胞瘤形成的发病机制。

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Thyroid cancer is one of the few malignancies that are increasing in incidence. Recent advances have improved our understanding of its pathogenesis; these include the identification of genetic alterations that activate a common effector pathway involving the RET-Ras-BRAF signalling cascade, and other unique chromosomal rearrangements. Some of these have been associated with radiation exposure as a pathogenetic mechanism. Defects in transcriptional and post-transcriptional regulation of adhesion molecules and cell-cycle control elements seem to affect tumour progression. This information can provide powerful ancillary diagnostic tools and can also be used to identify new therapeutic targets.

机译：甲状腺癌是少数几率不断上升的恶性肿瘤之一。最近的进展提高了我们对其发病机理的认识。这些包括鉴定可激活涉及RET-Ras-BRAF信号级联反应的常见效应子途径的遗传改变，以及其他独特的染色体重排。其中一些已经与放射线暴露作为致病机理有关。粘附分子和细胞周期控制元件的转录和转录后调控的缺陷似乎影响肿瘤的进展。该信息可提供强大的辅助诊断工具，还可用于识别新的治疗靶标。

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《Nature reviews Cancer》 |2006年第4期|共15页
作者
Kondo T; Ezzat S; Asa SL;
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正文语种 eng
中图分类肿瘤学;
关键词
Adenocarcinoma; Follicular; Thyroid Neoplasms; 腺癌; 滤泡性; 甲状腺肿瘤;

机译：Adenocarcinoma;Follicular;Thyroid Neoplasms;腺癌;滤泡性;甲状腺肿瘤;

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1. Pathogenetic mechanisms in thyroid follicular-cell neoplasia. [J] . Kondo T, Ezzat S, Asa SL Nature reviews Cancer . 2006,第4期

机译：甲状腺滤泡细胞瘤形成的发病机制。
2. Increase in thyroid follicular cell tumors in nelfinavir-treated rats observed in a 2-year carcinogenicity study is consistent with a rat-specific mechanism of thyroid neoplasia. [J] . Burns Naas LA, Zorbas M, Jessen B, Human and Experimental Toxicology . 2005,第12期

机译：在一项为期2年的致癌性研究中观察到，在用奈非那韦治疗的大鼠中，甲状腺滤泡细胞瘤的增加与大鼠甲状腺瘤形成的特定机制一致。
3. Molecular and genetic markers of follicular-cell thyroid cancer: Etiology and diagnostic and therapeutic opportunities [J] . GoyalN., SetabutrD., AbdulghaniJ., Advances in Experimental Medicine and Biology . 2013,第Null期

机译：滤泡性甲状腺癌的分子和遗传标志物：病因，诊断和治疗机会
4. Chemokine-based pathogenetic mechanisms in cancer [C] . Ilaria Conti, Christine Dube, Barrett J. Rollins Symposium on Cancer and inflammation . 2004

机译：基于趋化因子的癌症致病机制
5. Pathogenetic mechanisms of hemangioma endothelial cells [D] . Medici, Damian Darren 2008

机译：血管瘤内皮细胞的发病机制
6. Differential expression profile of CXCR3 splicing variants is associated with thyroid neoplasia. Potential role in papillary thyroid carcinoma oncogenesis? [O] . Soledad Urra, Martin C. Fischer, José R. Martínez, 2018

机译：CXCR3剪接变体的差异表达谱与甲状腺肿瘤相关。在甲状腺乳头状癌发生中可能发挥作用？
7. Functioning and non functioning thyroid adenomas involve different molecular pathogenetic mechanisms [O] . TONACCHERA M., VITTI P, AGRETTI P, 1999

机译：功能性和非功能性甲状腺腺瘤涉及不同的分子致病机制
8. Aspen Cancer Conference (8th): Molecular Mechanisms of Toxicity in Relation tothe Genetics of Animal and Human Neoplasia. Held on July 17-22, 1993 [R] . Tennant, R. W., Prescott, D. M., Puck, T. T., 1994

机译：aspen癌症会议（第8次）：与动物和人类肿瘤遗传学有关的毒性的分子机制。于1993年7月17日至22日举行

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Pathogenetic mechanisms in thyroid follicular-cell neoplasia.

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