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首页> 外文期刊>Nano: brief reports and reviews >NANOTECHNOLOGY IN PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS. DENDRIMERS
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NANOTECHNOLOGY IN PHARMACEUTICAL AND BIOMEDICAL APPLICATIONS. DENDRIMERS

机译：纳米技术在药物和生物医学领域的应用。装饰品

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摘要

Nanotechnology, a separate field of knowledge since 1980s, involves utilization of nanomaterials not only in electronics and catalysis, but also in biomedical research including drug delivery, bioimaging, biomedical-diagnostics and tissue engineering. Multidisciplinary of this science has led to the development of different areas of technology and might contribute to innovations that will, as a final consequence, help humanity. Dendrimers are large and complex molecules that are characterized by well-defined nanoscale architecture, monodispersity and structural versa-tility. These highly interesting polymers consist of three elements: core, branches and periph-eral groups. There is a wide variety of potential applications of dendritic polymers. One of the most promising is utilization of polyamidoamine (PAMAM) dendrimers as drug delivery devices. Among pharmaceuticals that have been connected with different types of dendrimers are nonsteroidal anti-inflammatory drugs (NSAIDs), anticancer drugs and other. Dendrimers application as drug carriers improves pharmacokinetic properties of drug particles, decreases drugs' side effects and, by possibility of surface modification with different ligands, enables to target specific tissues and tumor cells. Dendrimers might be also utilized as devices for delivery of genetic material and contrast agents for magnetic resonance imaging (MRI).
机译：纳米技术自1980年代以来一直是一个独立的知识领域，它不仅在电子和催化方面涉及纳米材料的利用，而且还涉及包括药物输送，生物成像，生物医学诊断和组织工程在内的生物医学研究。这种科学的多学科领域导致了技术的不同领域的发展，并可能有助于最终将帮助人类的创新。树枝状大分子是复杂的大分子，其特征是定义明确的纳米级结构，单分散性和结构通用性。这些非常有趣的聚合物由三个元素组成：核心，分支和外围基团。树突状聚合物具有多种潜在的应用。最有前途的方法之一是利用聚酰胺酰胺（PAMAM）树状聚合物作为药物输送装置。非甾体抗炎药（NSAIDs），抗癌药和其他药物已与不同类型的树枝状聚合物相关。树状聚合物作为药物载体的应用改善了药物颗粒的药代动力学特性，降低了药物的副作用，并且通过用不同的配体进行表面修饰的可能性，能够靶向特定的组织和肿瘤细胞。树枝状聚合物也可以用作传递遗传物质的设备和用于磁共振成像（MRI）的造影剂。

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