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Fabrication and in vitro biomineralization of bioactive glass (BG) nanofibres

机译：生物活性玻璃（BG）纳米纤维的制备和体外生物矿化

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Bioactive glass nanofibres have excellent bioactivity and cell compatibility, and are regarded as a promising next-generation biomaterial in the bone-regeneration field. This paper is concentrated on the effect of electrospinning parameters on the diameter and morphology of bioactive glass nanofibres, and the process of in vitro biomineralization. In this work, sol-gel glass nanofibres with high bioactivity were prepared by electrospinning processing in the presence of poly(vinyl pyrrolidone) (PVP) and pluronic P123 (EO_(20)-PO_(70)-EO_(20) as chain entanglements. The influence of the polymer concentration, types of polymer and electric field strength on the fibre diameter was examined. The average diameter of these BG nanofibres could be controlled in the range from 85 to 400 nm. The addition of PVP resulted in sufficient chain entanglement and the formation of smooth BG nanofibres, and the addition of P123 led to a further decrease of the diameter with appropriate electric field strength, which held the balance between the electrostatic repulsive force and surface tension of the electrospinning solution. Furthermore, the early stage of in vitro biomineralization of the BG nanofibres in the simulated body fluid (SBF) was studied in this work. The behaviour of in vitro biomineralization of bioactive glass nanofibres was different to the conventional ones, and the structure of bioactive glasses contributed to the formation process of hydroxyapatite.
机译：生物活性玻璃纳米纤维具有出色的生物活性和细胞相容性，被认为是骨再生领域中有希望的下一代生物材料。本文重点研究了电纺丝参数对生物活性玻璃纳米纤维直径和形貌的影响以及体外生物矿化的过程。在这项工作中，在聚乙烯吡咯烷酮（PVP）和普朗尼克P123（EO_（20）-PO_（70）-EO_（20）作为链缠结的情况下，通过电纺丝工艺制备了具有高生物活性的溶胶-凝胶玻璃纳米纤维。研究了聚合物浓度，聚合物类型和电场强度对纤维直径的影响，将这些BG纳米纤维的平均直径控制在85至400 nm范围内，加入PVP可使链缠结充分以及光滑的BG纳米纤维的形成，以及P123的加入导致直径的进一步减小以及适当的电场强度，从而在静电排斥力和静电纺丝溶液的表面张力之间保持平衡。本文研究了模拟体液（SBF）中BG纳米纤维的体外生物矿化作用，并区分了生物活性玻璃纳米纤维的体外生物矿化行为。与传统玻璃相比，生物活性玻璃的结构有助于羟基磷灰石的形成过程。

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