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Pathway discovery: The road to Ras and MAP kinase

机译：途径发现：Ras和MAP激酶之路

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In 1980 I was recruited to the Institute of Cancer Research (ICR) by its new director, Robin Weiss. After seven years as a postdoctoral fellow, at last I was a tenure-track faculty member and anxious to do something really interesting. During my time as a postdoc at the Sidney Farber Cancer Institute (now Dana-Farber Cancer Institute) in Harvard Medical School, I had been very impressed by Robert Weinbergs work showing that oncogenes could be detected in the DNA of chemically transformed cells by transfection of this DNA into normal NIH3T3 cells (R. A. Weinberg, Nat. CellBiol. 13, 876; 2011). This functional assay seemed to be the first clear way to clone cellular genes that cause cancer and so, as many others, I also wanted to try it. Fortunately, Alan Hall was recruited to the ICR soon after I was, and we set up a rewarding collaboration that led to the cloning of NRAS, the third member of the Ras gene family.
机译：1980年，我的新任主任Robin Weiss被招募到癌症研究所（ICR）。在担任博士后研究员七年之后，我终于成为终身制教师，并渴望做一些真正有趣的事情。在哈佛医学院Sidney Farber癌症研究所（现为Dana-Farber癌症研究所）担任博士后期间，Robert Weinbergs的研究给我留下了深刻的印象，该研究表明通过转染ADS可以检测到化学转化细胞DNA中的致癌基因。该DNA进入正常的NIH3T3细胞（RA Weinberg，Nat。CellBiol。13，876; 2011）。这项功能测定方法似乎是克隆导致癌症的细胞基因的第一个明确方法，因此，我也想尝试许多其他方法。幸运的是，艾伦·霍尔（Alan Hall）在我加入后不久就被招募到了ICR，我们建立了有益的合作关系，从而克隆了Ras基因家族的第三个成员NRAS。

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