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Active Wnt proteins are secreted on exosomes

机译：活性Wnt蛋白分泌在外泌体上

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Wnt signalling has important roles during development and in many diseases. As morphogens, hydrophobic Wnt proteins exert their function over a distance to induce patterning and cell differentiation decisions. Recent studies have identified several factors that are required for the secretion of Wnt proteins; however, how Wnts travel in the extracellular space remains a largely unresolved question. Here we show that Wnts are secreted on exosomes both during Drosophila development and in human cells. We demonstrate that exosomes carry Wnts on their surface to induce Wnt signalling activity in target cells. Together with the cargo receptor Evi/WIs, Wnts are transported through endosomal compartments onto exosomes, a process that requires the R-SNARE Ykt6. Our study demonstrates an evolutionarily conserved functional role of extracellular vesicular transport of Wnt proteins.
机译：Wnt信号传导在发育过程中和在许多疾病中具有重要作用。作为形态发生子，疏水性Wnt蛋白在一定距离内发挥其功能，从而诱导模式和细胞分化决策。最近的研究已经确定了分泌Wnt蛋白所需的几个因素。然而，Wnts如何在细胞外空间旅行仍然是一个悬而未决的问题。在这里，我们显示Wnts在果蝇发育过程中以及在人类细胞中都分泌在外泌体上。我们证明外泌体在其表面上携带Wnts以诱导靶细胞中的Wnt信号传导活性。 Wnt与货物受体Evi / WI一起通过内体区隔转运至外泌体，这一过程需要R-SNARE Ykt6。我们的研究表明Wnt蛋白的细胞外囊泡运输的进化保守功能作用。

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