...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature reviews. Genetics >Genetic predisposition to cancer - Insights from population genetics
【24h】

Genetic predisposition to cancer - Insights from population genetics

机译：癌症的遗传易感性-人口遗传学的见解

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Individuals differ in their inherited tendency to develop cancer. Major single-gene defects that cause early cancer onset have been known for many years from their inheritance patterns, and inherited defects that have weaker effects on predisposition were also suspected to exist. Recent progress in cancer genetics has identified specific loci that are involved in cancer progression, many of which have key roles in DNA repair, cell-cycle control and cell-death pathways. Those loci, which are often mutated somatically during cancer progression, sometimes also contain inherited mutations. Recent genetic studies and quantitative population-genetic analyses provide a framework for understanding the frequency of inherited mutations and the consequences of these mutations for increased predisposition to cancer.
机译：个体遗传癌症的倾向不同。导致早期癌症发作的主要单基因缺陷已从其遗传模式中获得了许多年的认识，并且也怀疑存在对易感性影响较弱的遗传缺陷。癌症遗传学的最新进展已经确定了与癌症进展有关的特定位点，其中许多位点在DNA修复，细胞周期控制和细胞死亡途径中具有关键作用。这些位点通常在癌症进展过程中发生体细胞突变，有时也包含遗传突变。最近的遗传研究和定量的种群遗传分析提供了一个框架，可用于了解遗传突变的频率以及这些突变对癌症易感性的影响。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号