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首页> 外文期刊>Nature reviews. Genetics >How did alternative splicing evolve?
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How did alternative splicing evolve?

机译：替代剪接如何演变？

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Alternative splicing creates transcriptome diversification, possibly leading to speciation. A large fraction of the protein-coding genes of multicellular organisms are alternatively spliced, although no regulated splicing has been detected in unicellular eukaryotes such as yeasts. A comparative analysis of unicellular and multicellular eukaryotic 5' splice sites has revealed important differences-the plasticity of the 5' splice sites of multicellular eukaryotes means that these sites can be used in both constitutive and alternative splicing, and for the regulation of the inclusion/skipping ratio in alternative splicing. So, alternative splicing might have originated as a result of relaxation of the 5' splice site recognition in organisms that originally could support only constitutive splicing.
机译：选择性剪接使转录组多样化，可能导致物种形成。尽管在单细胞真核生物如酵母菌中未检测到调控的剪接，但大部分剪接的多细胞生物蛋白质编码基因却被剪接。对单细胞和多细胞真核生物5'剪接位点的比较分析显示出重要的差异-多细胞真核生物5'剪接位点的可塑性意味着这些位点可用于组成性和替代剪接，以及用于调控内含物/替代拼接中的跳过率。因此，替代性剪接可能是由于原本只能支持组成性剪接的生物中5'剪接位点识别放松而导致的。

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