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Genome-wide transcription and the implications for genomic organization

机译：全基因组转录及其对基因组组织的影响

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Recent evidence of genome-wide transcription in several species indicates that the amount of transcription that occurs cannot be entirely accounted for by current sets of genome-wide annotations. Evidence indicates that most of both strands of the human genome might be transcribed, implying extensive overlap of transcriptional units and regulatory elements. These observations suggest that genomic architecture is not colinear, but is instead interleaved and modular, and that the same genomic sequences are multifunctional: that is, used for multiple independently regulated transcripts and as regulatory regions. What are the implications and consequences of such an interleaved genomic architecture in terms of increased information content, transcriptional complexity, evolution and disease states?
机译：最近在几个物种中进行全基因组转录的证据表明，目前的全基因组注释集不能完全解释发生的转录量。证据表明，人类基因组的大部分两条链都可能被转录，这意味着转录单位和调控元件广泛重叠。这些观察结果表明，基因组结构不是共线的，而是交错的和模块化的，并且相同的基因组序列是多功能的：即，用于多个独立调节的转录本并用作调节区。从增加的信息含量，转录复杂性，进化和疾病状态来看，这种交错的基因组架构有何含义和后果？

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