Location of Template on the Human Ribosome as Revealed from Data on Cross-Linking with Reactive mRNA Analogs

D.M.Graifer; G.G.Karpova; D.G.Knorre

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Location of Template on the Human Ribosome as Revealed from Data on Cross-Linking with Reactive mRNA Analogs

机译：从与反应性mRNA类似物交联的数据中揭示了模板在人核糖体上的位置

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In this review we summarize data on the location of template on the human ribosome that we obtained from cross-linking (affinity labeling) experiments using reactive mRNA analogs. Types of mRNA analogs, model complexes of these analogs with 8OS ribosomes, and methods for analysis of the ribosomal components (proteins and rRNA nucleotides) cross-linked with the mRNA analogs are reviewed. From analysis of the cross-linking data, we suggest a scheme for the arrangement of mRNA on the human ribosome and compare the organization of the mRNA binding center on human and Escherichia coli ribosomes.

机译：在这篇综述中，我们总结了人类核糖体上模板位置的数据，这些数据是我们使用反应性mRNA类似物通过交联（亲和标记）实验获得的。审查了mRNA类似物的类型，这些类似物与8OS核糖体的模型复合物以及与该mRNA类似物交联的核糖体成分（蛋白质和rRNA核苷酸）的分析方法。通过对交联数据的分析，我们提出了在人核糖体上mRNA排列的方案，并比较了人和大肠杆菌核糖体上mRNA结合中心的组织。

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《Biochemistry》 |2001年第6期|共18页
作者
D.M.Graifer; G.G.Karpova; D.G.Knorre;
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正文语种 eng
中图分类生物化学;
关键词
human ribosome; mRNA analog; mRNA binding center; affinity cross-linking; ribosomal RNA; ribosomal proteins;

机译：人核糖体;mRNA类似物;mRNA结合中心;亲和交联;核糖体RNA;核糖体蛋白;

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1. Location of Template on the Human Ribosome as Revealed from Data on Cross-Linking with Reactive mRNA Analogs [J] . D.M.Graifer, G.G.Karpova, D.G.Knorre Biochemistry . 2001,第6期

机译：从与反应性mRNA类似物交联的数据中揭示了模板在人核糖体上的位置
2. Protein environment of mRNA at the decoding site of 80S ribosomes from human placenta as revealed from affinity labeling with mRNA analogs – derivatives of oligoribonucleotides [J] . Konstantin N. Bulygin, Natalie B. Matasova, Dmitri M. Graifer, Biochimica et biophysica acta. Gene structure and expression . 1997,第3期

机译：从人类胎盘的80S核糖体的解码位点处的mRNA的蛋白质环境，通过与mRNA类似物（寡核糖核苷酸衍生物）的亲和标记揭示出
3. Template location on the human ribosome: Environment of the mRNA nucleotide adjacent to the A-site codon on the 3 '-side [J] . Demeshkina NA, Styazhkina VA, Bulygin KN, Russian journal of bioorganic chemistry . 2005,第3期

机译：人核糖体上的模板位置：3'侧与A位密码子相邻的mRNA核苷酸的环境
4. Reactivity and Mechanism of the Formaldehyde Cross-Linking Reaction of Proteins Revealed by Mass Spectrometry-Based Studies [C] . Xuan Ding, Savita Srinivasa, Juergen Kast American Society for Mass Spectrometry Conference on Mass Spectrometry and Allied Topics . 2011

机译：蛋白质甲醛交联反应的反应性和机制，蛋白质揭示的基于质谱基研究
5. Global analysis reveals differential regulation of mRNA decay in human Induced Pluripotent Stem cells. [D] . Neff, Ashley T. 2013

机译：全局分析揭示了人类诱导的多能干细胞中mRNA衰减的差异调节。
6. The path of mRNA through the Escherichia coli ribosome; site-directed cross-linking of mRNA analogues carrying a photo-reactive label at various points 3 to the decoding site. [O] . J Rinke-Appel, N Jünke, K Stade, 1991

机译：mRNA通过大肠杆菌核糖体的路径；带有光反应性标记的mRNA类似物的定点交联在解码位点3的各个点。
7. The path of mRNA through the Escherichia coli ribosome; site-directed cross-linking of mRNA analogues carrying a photo-reactive label at various points 3′ to the decoding site. [O] . J. Rinke-Appel, N. Jünke, K. Stade, 1991

机译：通过大肠杆菌核糖体mRNA的路径;携带在各个点3'到解码部位的载有光反应性标签的mRNA类似物的传送交联。

Location of Template on the Human Ribosome as Revealed from Data on Cross-Linking with Reactive mRNA Analogs

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