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首页> 外文期刊>Nature neuroscience >Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.
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Distinct functions of kainate receptors in the brain are determined by the auxiliary subunit Neto1.

机译：脑中海藻酸酯受体的不同功能由辅助亚基Neto1决定。

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摘要

Ionotropic glutamate receptors principally mediate fast excitatory transmission in the brain. Among the three classes of ionotropic glutamate receptors, kainate receptors (KARs) have a unique brain distribution, which has been historically defined by (3)H-radiolabeled kainate binding. Compared with recombinant KARs expressed in heterologous cells, synaptic KARs exhibit characteristically slow rise-time and decay kinetics. However, the mechanisms responsible for these distinct KAR properties remain unclear. We found that both the high-affinity binding pattern in the mouse brain and the channel properties of native KARs are determined by the KAR auxiliary subunit Neto1. Through modulation of agonist binding affinity and off-kinetics of KARs, but not trafficking of KARs, Neto1 determined both the KAR high-affinity binding pattern and the distinctively slow kinetics of postsynaptic KARs. By regulating KAR excitatory postsynaptic current kinetics, Neto1 can control synaptic temporal summation, spike generation and fidelity.
机译：离子型谷氨酸受体主要介导大脑中的快速兴奋性传递。在三类离子型谷氨酸受体中，海藻酸盐受体（KARs）具有独特的大脑分布，这在历史上已由（3）H-放射性标记的海藻酸盐结合定义。与异源细胞中表达的重组KARs相比，突触KARs具有特征性的上升时间和衰减动力学。但是，负责这些不同的KAR属性的机制仍不清楚。我们发现，小鼠大脑中的高亲和力结合模式和天然KAR的通道特性均由KAR辅助亚基Neto1决定。通过调节激动剂的结合亲和力和KAR的运动动力学，但不调节KAR的运动，Neto1既确定了KAR的高亲和力结合模式，又确定了突触后KAR的缓慢动力学。通过调节KAR兴奋性突触后电流的动力学，Neto1可以控制突触的时间总和，尖峰的产生和保真度。

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