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首页> 外文期刊>Natural product communications >Search for Skin-whitening Agent from Prunus Plants and the Molecular Targets in Melanogenesis Pathway of Active Compounds
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Search for Skin-whitening Agent from Prunus Plants and the Molecular Targets in Melanogenesis Pathway of Active Compounds

机译：从李属植物中寻找美白剂及活性化合物黑色素生成途径中的分子靶标

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In our research program for discovering novel skin-whitening materials, screening of extracts from flowers of some Prunus species was performed using an anti-tyrosinase assay. Among the tested plants, the flowers of P. persica showed the most potent inhibitory activity. In addition, P. persica also showed suppression of melanogenesis in B16 rat melanoma cells. The active principles of tyrosinase inhibition and suppression of melanogenesis were revealed to be an afzelin (3-O-α-L-rhamnosylkaempferol) and a flavanone, naringenin. The mechanism of the anti-melanogenesis effect of these two compounds was disclosed, for the first time, as the suppression of the expression of tyrosinase protein, which was controlled by the inhibition of phosphorylation of p38 MAPK. These findings show that these compounds could be candidates for the novel molecular target for a skin-whitening agent.
机译：在我们用于发现新型皮肤增白材料的研究程序中，使用抗酪氨酸酶测定法对一些李属植物的花朵中的提取物进行了筛选。在测试的植物中，百日草的花表现出最强的抑制活性。此外，百日草还显示出B16大鼠黑色素瘤细胞中黑色素生成的抑制作用。酪氨酸酶抑制和抑制黑素生成的活性原理被揭示为黄素（3-O-α-L-鼠李糖基kaempferol）和黄烷酮，柚皮素。首次公开了这两种化合物的抗黑色素生成作用的机制，是通过抑制p38 MAPK的磷酸化来抑制酪氨酸酶蛋白的表达。这些发现表明这些化合物可以作为皮肤增白剂的新型分子靶标的候选物。

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