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首页> 外文期刊>Natural product communications >Cytotoxic action of triterpene glycosides from sea cucumbers from the genus Cucumaria on mouse spleen lymphocytes. Inhibition of nonspecific esterase
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Cytotoxic action of triterpene glycosides from sea cucumbers from the genus Cucumaria on mouse spleen lymphocytes. Inhibition of nonspecific esterase

机译：黄瓜属海参中三萜糖苷对小鼠脾淋巴细胞的细胞毒作用。抑制非特异性酯酶

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摘要

Four triterpene glycosides from sea cucumbers belonging to the genus Cucumaria, okhotoside A_1-1 (1), cucumarioside A_0-1 (2), frondoside A (3) and cucumarioside A_2-2 (4) inhibit the activity of nonspecific esterase of mouse spleen lymphocytes. The dependence of the inhibitory activity of the glycosides on their structure is similar to that for hemolytic activity. The absence of inhibitory activity for the preparation Cumaside, which is a complex of cucumarioside A_2-2 and related compounds with cholesterol, shows a cholesterol-dependent character of the inhibitory action of the glycosides. The effective inhibitory concentrations of frondoside A and cucumarioside A_2-2 are significantly higher than the immunomodulatory doses of these glycosides.
机译：黄瓜属海参中的四萜三糖苷，okhotoside A_1-1（1），cucumarioside A_0-1（2），frondoside A（3）和cucumarioside A_2-2（4）抑制小鼠脾脏非特异性酯酶的活性淋巴细胞。糖苷抑制活性对其结构的依赖性与溶血活性的依赖性相似。黄瓜角苷A_2-2和相关化合物与胆固醇的复合物Cumaside没有抑制活性，这表明糖苷的抑制作用具有胆固醇依赖性。伏兰糖苷A和积雪草苷A_2-2的有效抑制浓度明显高于这些糖苷的免疫调节剂量。

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