Steroidal Aglycones from Stems of Marsdenia tenacissima that Inhibited the Hedgehog Signaling Pathway

Lin Zhang; Feng-yang Chen; Shi-fang Xu; Yi-ping Ye; Xiao-yu Li

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Steroidal Aglycones from Stems of Marsdenia tenacissima that Inhibited the Hedgehog Signaling Pathway

机译：来自马氏藤条茎的类固醇糖苷配基抑制刺猬信号通路。

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摘要

Two novel steroidal aglycones, together with four known ones, were isolated from the hydrolysis extract of the CHCl_3 soluble extract of the stems of Marsdenia tenacissima. Their structures were determined on the basis of chemical evidence and extensive spectroscopic methods, including ID and 2D NMR spectroscopy. These compounds displayed inhibition of the Hedgehog signaling pathway in vitro.

机译：从Marsdenia tenacissima茎的CHCl_3可溶性提取物的水解提取物中分离出两种新型甾体糖苷配基，以及四种已知的糖苷配基。它们的结构是根据化学证据和广泛的光谱方法（包括1D和2D NMR光谱）确定的。这些化合物在体外显示出对刺猬信号通路的抑制。

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《Natural product communications》 |2014年第2期|共2页
作者
Lin Zhang; Feng-yang Chen; Shi-fang Xu; Yi-ping Ye; Xiao-yu Li;
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正文语种 eng
中图分类自然科学总论;
关键词
Marsdenia tenacissima; Asclepiadaceae; Steroidal aglycone; Hedgehog signaling pathway.;

机译：马氏藤;马鞭草科;甾体糖苷配基;刺猬信号通路。;

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专利

1. Steroidal Aglycones from Stems of Marsdenia tenacissima that Inhibited the Hedgehog Signaling Pathway [J] . Lin Zhang, Feng-yang Chen, Shi-fang Xu, Natural product communications . 2014,第2期

机译：来自马氏藤条茎的类固醇糖苷配基抑制刺猬信号通路。
2. Polyoxypregnane Steroids from the Stems of Marsdenia tenacissima [J] . Yao S, To KKW, Wang YZ, Journal of natural products . 2014,第9期

机译：马氏藤条茎中的聚氧孕烯类固醇
3. Three New C21 Steroidal Glycosides from the Stems of Marsdenia tenacissima [J] . An-Yuan Zhang Xin Huang Ai-Min Tan, An-Yuan Zhang Xin Huang Ai-Min Tan Helvetica Chimica Acta . 2010,第11期

机译：来自马氏藤条茎的三种新型C21甾族糖苷
4. Screening of Sonic Hedgehog (Shh) Inhibitors in the Hedgehog Signaling Pathway from Traditional Chinese Medicine (TCM) Database Through Structure-Based Pharmacophore Design [C] . Ilmi Fadhilah Rizki, Mochammad Arfin Fardiansyah Nasution, Syafrida Siregar, International symposium on bioinformatics research and applications . 2018

机译：基于结构药理设计的中药（TCM）数据库中刺猬信号通路中声波刺猬（Shh）抑制剂的筛选
5. Cancer stem cells and the Hedgehog signaling pathway in breast cancer Sk-Br-3 cells [D] . Tolani, Bhairavi (Vivi) 2007

机译：乳腺癌Sk-Br-3细胞中的癌症干细胞和Hedgehog信号通路
6. GANT61 and Valproic Acid Synergistically Inhibited Multiple Myeloma Cell Proliferation via Hedgehog Signaling Pathway [O] . Zhihua Zhang, Rongjuan Zhang, Changlai Hao, 2020

机译：GANT61和丙戊酸通过刺猬信号通路协同抑制多发性骨髓瘤细胞增殖。
7. Steroidal Aglycones from Stems of Marsdenia tenacissima that Inhibited the Hedgehog Signaling Pathway [O] . Lin Zhang, Feng-yang Chen, Shi-fang Xu, 2014

机译：来自Marsdenia Tenacissima的甾醇糖基，抑制了刺猬信号通路

Steroidal Aglycones from Stems of Marsdenia tenacissima that Inhibited the Hedgehog Signaling Pathway

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