Cytotoxic activity of cycloartane triterpenoids from Sphaerophysa salsula

Wang D.; Ma Z.

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Cytotoxic activity of cycloartane triterpenoids from Sphaerophysa salsula

机译：莎草（Sphaerophysa salsula）中环戊烷三萜类化合物的细胞毒活性

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The cytotoxicity of three cycloartane triterpenoids, 9,19-cycloart-7β, 24R, 25- triol-1-en-3-one (1), 9,19-cycloart-7β, 24R, 25-triol-1-en-3-one 25-O-β-D-glucopynanoside (2), and 25-O-β-D-arabinopyranosyl-(1→4) - β-D-glucopyranosyl-9,19-cycloart-7β, 24R, 25-triol-1-en-3-one (3), isolated from Sphaerophysa salsula was investigated on SF188, U87wt, MCF-7, and H460 cancer cell lines. Compound 1 showed the strongest activity. Cell cycle analysis was employed to elucidate the cytotoxicity on the tested U87wt cells, which led to G2/M arrest. In addition, from the Western blotting experiments, the expression of P21 is increased.

机译：三种环烷三萜，9,19-cycloart-7β，24R，25-三醇-1-en-3-one（1），9,19-cycloart-7β，24R，25-triol-1-en-的细胞毒性3-one25-O-β-D-吡喃葡萄糖苷（2）和25-O-β-D-阿拉伯吡喃糖基-（1→4）-β-D-吡喃葡萄糖基-9,19-cycloart-7β，24R，25在SF188，U87wt，MCF-7和H460癌细胞系上研究了从莎草鳞茎分离的-triol-1-en-3-one（3）。化合物1显示出最强的活性。使用细胞周期分析来阐明对受试U87wt细胞的细胞毒性，从而导致G2 / M阻滞。另外，根据蛋白质印迹实验，P21的表达增加。

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《Natural product communications》 |2009年第1期|共3页
作者
Wang D.; Ma Z.;
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正文语种 eng
中图分类自然科学总论;
关键词
Cell cycle; Cycloartane triterpenoids; Cytotoxicity; P21; Sphaerophysa salsula;

机译：细胞周期;环烷三萜;细胞毒性;P21;莎草;

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1. A New Cycloartane from Sphaerophysa salsula [J] . 中国化学快报（英文版） . 2003,第006期
2. Two New 9, 10-seco-Cycloartanes from the Seeds of Sphaerophysa salsula [J] . Zhong Jun MA, Isao FUJII, Yutaka EBIZUKA, 中国化学快报（英文版） . 2004,第001期

机译：莎草（Sphaerophysa salsula）种子中的两个新的9、10-seco-Cycloartanes
3. Cytotoxic activity of cycloartane triterpenoids from Sphaerophysa salsula [J] . Wang D., Ma Z. Natural product communications . 2009,第1期

机译：莎草（Sphaerophysa salsula）中环戊烷三萜类化合物的细胞毒活性
4. Two new 9,10-seco-cycloartanes from the seeds of Sphaerophysa salsula. [J] . Ma ZJ, Wang N, Fujii I, Journal of Asian natural products research . 2006,第7期

机译：莎草（Sphaerophysa salsula）种子中的两个新9,10-seco-环烷。
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6. Synthesis, conformational analysis and cytotoxic activity of friedelane triterpenoids. [D] . Ruan, Xiaoli. 2003

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8. Bioassay-guided isolation of cytotoxic cycloartane triterpenoid glycosides from the traditionally used medicinal plant Leea Indica [O] . Wong Y.H., Abdul Kadir H., Ling S.K. 2012

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Cytotoxic activity of cycloartane triterpenoids from Sphaerophysa salsula

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