Possible Role of Fat Tissue in the Pharmacokinetics of Dodeca-2E,-4E,8Z,10E/Z,10E/Z-tetraenoic Acid Isobutylamides after Oral Administration of Echinacea angustifolia Extract in Rats

Nikoletta Jedlinszki; Dóra Rédei; József Haller; Tamás F. Freund; Judit Hohmann; István Zupkó

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Possible Role of Fat Tissue in the Pharmacokinetics of Dodeca-2E,-4E,8Z,10E/Z,10E/Z-tetraenoic Acid Isobutylamides after Oral Administration of Echinacea angustifolia Extract in Rats

机译：口服紫锥菊提取物在大鼠中Dodeca-2E，-4E，8Z，10E / Z，10E / Z-丁烯酸异丁酰胺的药代动力学中脂肪组织的可能作用

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Alkamides are one of the most important constituents of lipophilic extracts of Echinacea angustifolia roots. These compounds play an important role in the versatile pharmacological actions of this plant. The present study aimed to compare the concentrations of isomeric dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides (DTAI) in brain and periepididymal fat tissues and blood plasma of rats. Thirty, 60, 240 and 720 min after the oral administration of E. angustifolia root extract, tissue and plasma concentrations were determined by reversed-phase HPLC with ESI-MS/MS detection. The calculated terminal t_(1/2) of the mixture of DTAI was 8.28 h, which indicates a relatively slow elimination. In the 0.5-4 h period the brain/plasma and fat/plasma concentration ratios were continuously above 3 and 18, respectively, followed by equilibrium at 12 h. Our results indicate substantial accumulation of alkamides in lipid-rich tissues, which presumably contributes to a maintained pharmacological action.

机译：链烷酰胺是松果紫锥菊根的亲脂性提取物中最重要的成分之一。这些化合物在该植物的多种药理作用中起重要作用。本研究旨在比较大鼠脑和上皮周围脂肪组织和血浆中同分异构体dodeca-2E，4E，8Z，10E / Z-丁烯酸异丁酰胺（DTAI）的浓度。口服给予马尾草根提取物后第30、60、240和720分钟，采用ESI-MS / MS检测的反相HPLC测定组织和血浆浓度。 DTAI混合物的最终末端t_（1/2）为8.28 h，表明清除速度相对较慢。在0.5-4小时内，脑/血浆和脂肪/血浆的浓度比分别连续高于3和18，然后在12小时达到平衡。我们的结果表明，在富含脂质的组织中大量积累了酰胺，这可能有助于维持药理作用。

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来源
《Natural product communications》 |2014年第6期|共3页
作者
Nikoletta Jedlinszki; Dóra Rédei; József Haller; Tamás F. Freund; Judit Hohmann; István Zupkó;
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正文语种 eng
中图分类自然科学总论;
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HPLC-MS/MS; Pharmacokinetics; Echinacea angustifolia; Alkamide; Dodeca-2E; 4E; 8Z; 10E/Z-tetraenoic acid isobutylamides.;

机译：HPLC-MS / MS;药代动力学;紫锥菊;烷基酰胺;Dodeca-2E;4E;8Z;10E / Z-丁烯酸异丁酰胺;

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1. Possible Role of Fat Tissue in the Pharmacokinetics of Dodeca-2E,-4E,8Z,10E/Z,10E/Z-tetraenoic Acid Isobutylamides after Oral Administration of Echinacea angustifolia Extract in Rats [J] . Nikoletta Jedlinszki, Dóra Rédei, József Haller, Natural product communications . 2014,第6期

机译：口服紫锥菊提取物在大鼠中Dodeca-2E，-4E，8Z，10E / Z，10E / Z-丁烯酸异丁酰胺的药代动力学中脂肪组织的可能作用
2. Pharmacokinetics and tissue distribution of dodeca-2E,4E,8E,10E/Z-tetraenoic acid isobutylamides after oral administration in rats. [J] . Woelkart K, Frye RF, Derendorf H, Planta medica: Natural products and medicinal plant research . 2009,第12期

机译：大鼠口服给药后dodeca-2E，4E，8E，10E / Z-丁烯酸异丁酰胺的药代动力学和组织分布。
3. The bioanalysis of the major Echinacea purpurea constituents dodeca-2E,4E,8Z,10E/Z-tetraenoic acid isobutylamides in human plasma using LC-MS/MS [J] . Goey A.K.L., Rosing H., Meijerman I., Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2012,第Null期

机译：使用LC-MS / MS对人体血浆中紫锥菊的主要成分dodeca-2E，4E，8Z，10E / Z-丁烯酸异丁酰胺进行生物分析
4. Simultaneous Determination and Pharmacokinetic Studies on (3,4-Dihydroxyphenyl)-Lactic Acid and Protocatechuic Aldehyde in Rat Serum after Oral Administration of Radix Salviae Miltiorrhizae Extract [C] . 北京大学中医药现代研究中心2003年年会论文集 . 2004

机译：丹参提取物口服后大鼠血清中（3,4-二羟基苯基）-乳酸和原儿茶醛的同时测定和药代动力学研究
5. Effect of Echinacea angustifolia root extracts and caffeic acid derivatives on cancer cell proliferation [D] . Huntimer, Eric 2005

机译：紫锥菊的根提取物和咖啡酸衍生物对癌细胞增殖的影响
6. Bioavailability of dodeca-2E 4E 8E 10E/Z-tetraenoic acid isobutylamides after oral administration in rats and distribution in various tissues [O] . Karin Wölkart, Reginald Frye, Hartmut Derendorf, 2009

机译：大鼠口服给药后dodeca-2E4E8E10E / Z-丁烯酸异丁酰胺的生物利用度并在各种组织中分布
7. Possible role of fat tissue in the pharmacokinetics of dodeca-2E,4E,8Z,10E/ Z-tetraenoic acid isobutylamides after oral administration of Echinacea angustifolia extract in rats [O] . Jedlinszki Nikoletta, Rédei Dóra, Haller József, 2014

机译：口服紫锥菊提取物在大鼠中给药后脂肪组织在dodeca-2E，4E，8Z，10E / Z-丁烯酸异丁酰胺药代动力学中的可能作用

Possible Role of Fat Tissue in the Pharmacokinetics of Dodeca-2E,-4E,8Z,10E/Z,10E/Z-tetraenoic Acid Isobutylamides after Oral Administration of Echinacea angustifolia Extract in Rats

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