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首页> 外文期刊>Natural product communications >A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties
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A New Source of (R)-Limonene and Rotundifolone from Leaves of Lippia pedunculosa (Verbenaceae) and their Trypanocidal Properties

机译：马齿Li（Lippia pedunculosa（Verbenaceae））叶片中（R）-柠檬烯和扶轮酮的新来源及其锥虫特性

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摘要

Investigation by GC-FID and GC-MS of the essential oil (LPOE) from the leaves of Lippia pedunculosa revealed, as the major compounds, the monoterpenes rotundifolone (71.7%) and (R)-limonene (21.8%). These two compounds and the minor constituent piperitenone (1.2%) were also isolated from the leaves and identified by spectrometric analysis. LPOE and isolated compounds were evaluated for their trypanocidal activity against epimastigote and trypomastigote forms of Trypanosoma cruzi. Significant results with IC_(50) values lower than 34.0 μg.mL~(-1) were observed against these forms of T. cruzi for LPOE and isolated compounds. Rotundifolone was the most active compound with an IC_(50) lower than 10.0 μg.mL~(-1) for both forms of T. cruzi. The effects of LPOE and isolated compounds were also evaluated in cultures of macrophages infected with T. cruzi. Treatment with (R)-limonene and rotundifolone caused a moderate reduction in the percentage of macrophages infected by T. cruzi and in the number of intracellular parasites at concentrations non-toxic to macrophages.
机译：通过GC-FID和GC-MS对小脚草（Lippia pedunculosa）叶片中的香精油（LPOE）进行的研究表明，主要成分为单萜类化合物rotundifolone（71.7％）和（R）-柠檬烯（21.8％）。这两种化合物和次要成分哌啶酮（1.2％）也从叶子中分离出来并通过光谱分析鉴定。评估了LPOE和分离的化合物对克氏锥虫的副鞭毛和锥鞭毛形式的锥虫杀虫活性。对于LPOE和分离的化合物的这些形式的克鲁氏梭菌，观察到IC_（50）值低于34.0μg.mL〜（-1）的显着结果。曲霉酮是活性最高的化合物，两种形式的克氏锥虫的IC_（50）均低于10.0μg.mL〜（-1）。 LPOE和分离的化合物的影响也评估了感染克氏锥虫巨噬细胞的培养。 （R）-柠檬烯和Rotundifolone的处理导致被克鲁维螺旋体感染的巨噬细胞百分比和对巨噬细胞无毒浓度的细胞内寄生虫数量适度降低。

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