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首页> 外文期刊>Natural product communications >Chemical Composition, and CytotoXic, Antioxidant and Antibacterial Activities of the Essential Oil from Ginseng Leaves
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Chemical Composition, and CytotoXic, Antioxidant and Antibacterial Activities of the Essential Oil from Ginseng Leaves

机译：人参叶精油的化学成分，细胞毒性，抗氧化和抗菌活性

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Panax ginseng C.A.Meyer is one of the most valuable traditional Chinese medicines. In this study, the essential oil of ginseng leaves (EOGL), collected using hydrodistillation and analyzed by GC/MS, contained a complex mixture of aliphatic (69.0%), terpenoid (21.5%) and aromatic compounds (2.4%). Among 54 components identified, the major ones were palmitic acid (36.1%), β-farnesene (15.4%), linoleic acid (9.8%) and phytol (5.6%). In the cytotoxicity study, EOGL exhibited obvious cytotoxic activities against different cancer cell lines, including Hela, A549, ZR-75-1, HT-29, SGC7901 and B16 cells. Furthermore, Annexin V-FITC/PI staining assay indicated that EOGL can induce late apoptosis of ZR-75-1 cells, and the percentage of apoptotic cells increased in a concentration-dependent manner (0.9% to 5.6% and 67.4%). In addition to this, we also found that EOGL exhibited weak DPPH radical scavenging (12.0 ± 0.4 mg/mL) and ABTS radical scavenging activities (1.6 ± 0.1 mg/mL), and showed antibacterial activity against the Gram-positive bacteria, Staphylococcus aureus and Bacillus subtilis, and the Gram-negative bacterium, Escherichia coli. The data suggest that EOGL, which possesses important biological activities, especially significant anticancer activity, could be a potential medicinal resource.
机译：人参C.A.迈耶是最有价值的中药之一。在这项研究中，人参叶精油（EOGL）通过加氢蒸馏收集并通过GC / MS分析，其中包含脂族（69.0％），萜类（21.5％）和芳族化合物（2.4％）的复杂混合物。在确定的54种成分中，主要成分为棕榈酸（36.1％），β-法呢烯（15.4％），亚油酸（9.8％）和植醇（5.6％）。在细胞毒性研究中，EOGL对不同的癌细胞系（包括Hela，A549，ZR-75-1，HT-29，SGC7901和B16细胞）表现出明显的细胞毒性活性。此外，Annexin V-FITC / PI染色试验表明，EOGL可以诱导ZR-75-1细胞的晚期凋亡，并且凋亡细胞的百分比呈浓度依赖性增加（0.9％至5.6％和67.4％）。除此之外，我们还发现EOGL表现出弱的DPPH自由基清除能力（12.0±0.4 mg / mL）和ABTS自由基清除活性（1.6±0.1 mg / mL），并且对革兰氏阳性细菌金黄色葡萄球菌具有抗菌活性和枯草芽孢杆菌，以及革兰氏阴性细菌大肠杆菌。数据表明，具有重要生物活性，特别是重要的抗癌活性的EOGL可能是潜在的药用资源。

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