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首页> 外文期刊>Natural product communications >Biological Activity of Dolichandrone serrulata Flowers and Their Active Components
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Biological Activity of Dolichandrone serrulata Flowers and Their Active Components

机译：绢毛杜鹃花的生物活性及其活性成分

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Dolichandrone serrulata (DC.) Seem flowers are widely used as vegetables in northern and eastern Thailand. Biological studies of the methanolic extract of these flowers have shown promising antioxidant activity. Biological-guided separation of D. serrulata flowers yielded six compounds, identified as hallerone, protocatechuic acid, rengyolone, cleroindicin B, ixoside, and isomaltose. This is the first report on hallerone, protocatechuic acid, rengyolone, cleroindicin B, and isomaltose in D. serrulata. Protocatechuic acid was the most potent scavenger of 2,2-diphenyl-l-picryihydrazyl and hydroxyl radicals with IC50 values of 25.6 +/- 0.6 and 29.6 +/- 0.4 mu M, respectively. Hallerone and rengyolone showed moderate scavenging action on superoxide radicals and inhibited H2O2 induced reactive oxygen species production in HEK-293 cell. In addition, the other isolated compounds showed weak activity.
机译：Dolichandrone serrulata（DC。）似花在泰国北部和东部被广泛用作蔬菜。这些花的甲醇提取物的生物学研究表明，其抗氧化活性很有希望。用生物引导法分离出桔梗D.花，得到了6种化合物，分别为哈雷酮，原儿茶酸，藤黄酮，氯霉素B，ixoside和异麦芽糖。这是关于D. serrulata中哈雷酮，原儿茶酸，伦戈隆，氯青霉素B和异麦芽糖的首次报道。原儿茶酸是最有效的2,2-二苯基-1-吡啶二酰肼基和羟基自由基的清除剂，IC50值分别为25.6 +/- 0.6和29.6 +/- 0.4μM。 Hallerone和rengyolone在HEK-293细胞中表现出对超氧自由基的适度清除作用，并抑制H2O2诱导的活性氧生成。另外，其他分离的化合物显示出弱的活性。

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