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首页> 外文期刊>Natural product communications >Phytochemical Screening of Garcinia travancorica by HPLC-ESI-QTOF Mass Spectrometry and Cytotoxicity Studies of the Major Biflavonoid Fukugiside
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Phytochemical Screening of Garcinia travancorica by HPLC-ESI-QTOF Mass Spectrometry and Cytotoxicity Studies of the Major Biflavonoid Fukugiside

机译：HPLC-ESI-QTOF质谱分析藤黄藤的植物化学成分及主要双黄酮类福建甙的细胞毒性研究

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Qualitative screening of multiclass secondary metabolites present in the fruits, leaves and stem bark extracts of Garcinia travancorica was carried out using HPLC-QTOF-MS analysis. Twenty-three compounds were identified in the fruits, leaves and stem bark, including two acids (hydroxycitric acid and hydroxycitric acid lactone), eight biflavonoids (morelloflavone, GB-1, GB-1 a, GB-2, GB-2a, fukugiside, xanthochymusside and GB-la glucoside), nine xanthones (alpha-mangostin, gamma-mangostin, 1,5-dihydroxy-3-methoxyxanthone, garciniaxanthone E, 4-(1,1-dimethylprop-2-enyl)-1,3,5,8-tetrahydroxy-xanthone, garcinone A, garcinone B, garcinone C and polyanxanthone C) and four polyisoprenylated benzophenones (gambogenone, aristophenone A, garcinol and garciyunnanin A). Cytotoxicity studies of the major biflavonoid fukugiside reported from G. travancorica leaves revealed a dose-dependent cancer cell growth inhibition in A431 and HeLa cells. The antiproliferative effect appears to be due to the ability of fukugiside to induce S-phase arrest and apoptotic cell death. In HeLa cells, fukugiside reduced the expression of MAPKp38 by 26.1% compared with untreated control.
机译：使用HPLC-QTOF-MS分析法对桔梗的果实，叶片和茎皮提取物中存在的多种次要代谢产物进行了定性筛选。在水果，树叶和茎皮中鉴定出23种化合物，包括两种酸（羟基柠檬酸和羟基柠檬酸内酯），八种双黄酮类化合物（莫来黄酮，GB-1，GB-1a，GB-2，GB-2a，福建甙） ，黄原肌苷和GB-1a糖苷），九种黄原酮（α-芒果，γ-芒果，1,5-二羟基-3-甲氧基黄酮，藤黄酮E，4-（1,1-二甲基丙-2-烯基）-1,3 ，5，8-四羟基黄酮，藤黄酮A，藤黄酮B，藤黄酮C和聚蒽酮C）和四种聚异戊二烯基化的二苯甲酮（藤黄酮，马兜铃酮A，藤黄酚和藤黄酮A）。从travancorica叶报道的主要双黄酮类福建甙的细胞毒性研究显示，A431和HeLa细胞具有剂量依赖性的癌细胞生长抑制作用。该抗增殖作用似乎是由于福冈糖苷具有诱导S期停滞和凋亡细胞死亡的能力。与未处理的对照组相比，在福建霉素的HeLa细胞中，MAPKp38的表达降低了26.1％。

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