Impaired ghymic development in mouse embryos deficient in apoptotic DNA degradation

Kohki Kawane; Hidehiro Fukuyama; Hideyuki Yoshida; Hiroko Nagase; Yoshiyuki Oshsawa; Kazuhisa Okada; Tetsuya Iida; Shigekazu Nagata

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Impaired ghymic development in mouse embryos deficient in apoptotic DNA degradation

机译：缺乏凋亡DNA降解的小鼠胚胎的运动发育受损

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Apoptosis is often accompanied by the degradation of chromosomal DNA, Caspase-activated DNase (CAD) is an endonuclease that is activated in dying cells, whereas DNase II is present in the lysosomes of macrophages. Here, we show that CAD~(-/-) thymocyts did not undergo apoptotic DNA degradation. But, when apoptotic cells were phagocytosed by macrophages, their DNA was degraded by DNase II. The thymus of DNase II~(-/-)CAD~(-/-) embryos contained many foci carrying undigested DNA and the cellularity was severely reduced due to a block in T cell development. The interferon-β gene was strongly up-regulated in the thymus of DNase II~(-/-)CAD~(-/-) embryos, suggesting that when the DNA of apoptotic cells is left undigested, it can activate innate immunity leading to defects in thymic development.

机译：细胞凋亡通常伴随着染色体DNA的降解，胱天蛋白酶激活的DNase（CAD）是一种在死亡细胞中被激活的内切核酸酶，而DNase II存在于巨噬细胞的溶酶体中。在这里，我们显示CAD〜（-/-）胸腺细胞未经历凋亡性DNA降解。但是，当凋亡细胞被巨噬细胞吞噬时，它们的DNA被DNase II降解。 DNase II〜（-/-）CAD〜（-/-）胚胎的胸腺含有许多携带未消化的DNA的病灶，并且由于T细胞发育受阻而严重降低了细胞性。干扰素-β基因在DNase II〜（-/-）CAD〜（-/-）胚胎的胸腺中强烈上调，表明当凋亡细胞的DNA不被消化时，它可以激活先天免疫从而导致胸腺发育缺陷。

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《Nature immunology》 |2003年第2期|共7页
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Kohki Kawane; Hidehiro Fukuyama; Hideyuki Yoshida; Hiroko Nagase; Yoshiyuki Oshsawa; Kazuhisa Okada; Tetsuya Iida; Shigekazu Nagata;
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1. Impaired ghymic development in mouse embryos deficient in apoptotic DNA degradation [J] . Kohki Kawane, Hidehiro Fukuyama, Hideyuki Yoshida, Nature immunology . 2003,第2期

机译：缺乏凋亡DNA降解的小鼠胚胎的运动发育受损
2. Clearance of apoptotic cells is not impaired in mouse embryos deficient in class A scavenger receptor types I and II (CD204). [J] . Komohara Y, Terasaki Y, Kaikita K, Developmental dynamics: an official publication of the American Association of Anatomists . 2005,第1期

机译：缺乏I类和II类A类清道夫受体（CD204）的小鼠胚胎中，凋亡细胞的清除不会受到损害。
3. Embryo transfer catheter contamination with intravaginal progesterone preparations in a simulated embryo transfer model impairs mouse embryo development: Are there implications for human embryo transfer technique? [J] . YingL.Y., YingY., MayerJ., Reproductive sciences . 2014,第8期

机译：在模拟的胚胎移植模型中，阴道内孕激素制剂对胚胎移植导管的污染损害了小鼠胚胎的发育：这对人类胚胎移植技术有影响吗？
4. Tocotrienol improves the quality of impaired mouse embryos induced by corticosterone [C] . Nasibah A., Rajikin M.H., Nor-Ashikin M.N.K., 2012 IEEE Colloquium on Humanities, Science and Engineering Research . 2012

机译：生育三烯酚可改善皮质酮诱导的受损小鼠胚胎的质量
5. Trafficking of cathepsin B-EGFP fusion proteins in human breast adenocarcinoma cells and cathepsin B deficient mouse embryo fibroblasts. [D] . Demchik, Lisa Lois. 2002

机译：组织蛋白酶B-EGFP融合蛋白在人乳腺腺癌细胞和组织蛋白酶B缺陷的小鼠胚胎成纤维细胞中的运输。
6. The Roles and Acting Mechanism of Caenorhabditis elegans DNase II Genes in Apoptotic DNA Degradation and Development [O] . Huey-Jen Lai, Szecheng J. Lo, Eriko Kage-Nakadai, 2009

机译：秀丽隐杆线虫DNase II基因在凋亡DNA降解和发育中的作用和作用机制
7. Clearance of apoptotic cells is not impaired in mouse embryos deficient in class A scavenger receptor types I and II (CD204) [O] . Yoshihiro Komohara, Yasuhiro Terasaki, Koichi Kaikita, 2004

机译：在清除剂受体类型I和II类中，小鼠胚胎缺乏凋亡细胞的间隙在小鼠胚胎中不损害（CD204）
8. Developmental Toxicity of Methanol in Whole Embryo Culture: A Comparative Studywith Mouse and Rat Embryos [R] . Andrews, J. E., Ebron-McCoy, M., Logsdon, T. R., 1993

机译：甲醇在整个胚胎培养中的发育毒性：与小鼠和大鼠胚胎的比较研究

Impaired ghymic development in mouse embryos deficient in apoptotic DNA degradation

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