Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction

Welte S; Kuttruff S; Waldhauer I; Steinle A

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Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction

机译：NKp80-AICL相互作用介导的自然杀伤细胞和单核细胞的相互激活

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Receptors encoded by the natural killer (NK) cell gene complex (such as NKG2D) govern the reactivity of NK cells. However, the function and ligand(s) of the NK cell gene complex-encoded human NK cell receptor NKp80 remain elusive. Here we demonstrate that NKp80 binds to the genetically linked 'orphan' receptor AICL, which, like NKp80, is absent from rodents. We defined AICL as a myeloid-specific activating receptor that is upregulated by Toll-like receptor stimulation. AICL-NKp80 interactions promoted NK cell-mediated cytolysis of malignant myeloid cells. In addition, during crosstalk between NK cells and monocytes, NKp80 stimulated the release of proinflammatory cytokines from both cell types. Thus, by specifically bridging NK cells and myeloid cells, NKp80-AICL interactions may contribute to the initiation and maintenance of immune responses at sites of inflammation.

机译：由自然杀伤（NK）细胞基因复合物（例如NKG2D）编码的受体控制NK细胞的反应性。但是，NK细胞基因复合物编码的人NK细胞受体NKp80的功能和配体仍然难以捉摸。在这里，我们证明了NKp80与遗传连接的“孤儿”受体AICL结合，而该动物与NKp80一样，是啮齿动物所不具备的。我们将AICL定义为通过Toll样受体刺激上调的髓样特异性激活受体。 AICL-NKp80相互作用促进了恶性骨髓细胞的NK细胞介导的细胞溶解。此外，在NK细胞与单核细胞之间的串扰期间，NKp80刺激了两种细胞中促炎性细胞因子的释放。因此，通过特异地桥接NK细胞和髓样细胞，NKp80-AICL相互作用可有助于炎症部位的免疫应答的起始和维持。

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《Nature immunology》 |2006年第12期|共9页
作者
Welte S; Kuttruff S; Waldhauer I; Steinle A;
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正文语种 eng
中图分类基础医学;
关键词
NK GENE-COMPLEX; DENDRITIC CELLS; CUTTING EDGE; PLASMODIUM-FALCIPARUM; NKG2D RECEPTOR; MISSING SELF; T-CELLS; IN-VIVO; EXPRESSION; RESPONSES;

机译：NK基因复合物;树突状细胞;切缘;恶性疟原虫;NKG2D受体;自我缺失;T细胞;体内;表达;反应;

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1. Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction [J] . Welte S, Kuttruff S, Waldhauer I, Nature immunology . 2006,第12期

机译：NKp80-AICL相互作用介导的自然杀伤细胞和单核细胞的相互激活
2. Mutual activation of CD4+ T cells and monocytes mediated by NKG2D-MIC interaction requires IFN-gamma production in systemic lupus erythematosus. [J] . Yang D, Wang H, Ni B, Molecular Immunology . 2009,第7期

机译：NKG2D-MIC相互作用介导的CD4 + T细胞和单核细胞的相互激活需要在系统性红斑狼疮中产生IFN-γ。
3. SLAM family receptors in natural killer cells - Mediators of adhesion, activation and inhibition via cis and trans interactions [J] . Claus Maren, Urlaub Doris, Fasbender Frank, Clinical immunology: The official journal of the Clinical Immunology Society . 2019,第期

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4. Orthopedic Implant Particle-Induced Tumor Necrosis Factor-a Production in Macrophage–Monocyte Lineage Cells Is Mediated by Nuclear Factor of Activated T Cells [C] . HIROSHI MINEMATSU, MIKE J. SHIN, AYSE B. CELIL AYDEMIR, Conference on Skeletal Biology and Medicine . 2007

机译：矫形植入物颗粒诱导的肿瘤坏死因子 - 巨噬细胞单核细胞谱系细胞的产生是由活化T细胞的核因子介导的
5. In vitro expanded natural killer (NK) cells are more susceptible to Fas mediated apoptosis compared to fresh or overnight IL-2 activated NK cells. [D] . Betters, Dawn Marie. 2011

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6. Glioblastoma Stem-Like Cells Are More Susceptible Than Differentiated Cells to Natural Killer Cell Lysis Mediated Through Killer Immunoglobulin-Like Receptors–Human Leukocyte Antigen Ligand Mismatch and Activation Receptor–Ligand Interactions [O] . Heleen Neeltje Haspels, Mohummad Aminur Rahman, Justin Vareecal Joseph, -1

机译：胶质母细胞瘤干细胞比分化细胞对通过杀手免疫球蛋白样受体-人白细胞抗原配体错配和活化受体-配体相互作用介导的自然杀伤细胞裂解的敏感性更高。
7. Interaction of natural killer cells with MHC class II: reversal of HLA-DR1-mediated protection of K562 transfectant from natural killer cell-mediated cytolysis by brefeldin-A. [O] . Jiang, Y Z, Couriel, D, Mavroudis, D A, 1996

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Mutual activation of natural killer cells and monocytes mediated by NKp80-AICL interaction

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