Linking diacylglycerol kinase to T cell anergy.

Mueller DL

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Linking diacylglycerol kinase to T cell anergy.

机译：将二酰基甘油激酶与T细胞无反应联系起来。

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Just over 20 years ago, it was reported that human cloned T cells enter a state of unre-sponsiveness when allowed to present antigen to each other1. Shortly thereafter, an analogous form of tolerance was noted in vitro and in vivo in mouse T cells exposed to antigen in the presence of 'costimulation-poor', chemically modified antigen-presenting cells2 or purified major histocompatibility complex class II molecules3. In both experimental systems, 'anergic' T cells were incapable of proliferating after rechallenge with antigen, at least in part because of their inability to produce interleukin 2 (IL-2).

机译：就在20多年前，据报道，人类克隆的T细胞在允许彼此呈递抗原时会进入无反应状态。此后不久，在“共刺激性差”，化学修饰的抗原呈递细胞2或纯化的主要组织相容性复合体II类分子3的存在下，暴露于抗原的小鼠T细胞在体内和体外都表现出相似的耐受性。在这两个实验系统中，“无反应性” T细胞在用抗原攻击后均无法增殖，至少部分是由于它们无法产生白介素2（IL-2）。

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来源
《Nature immunology》 |2006年第11期|共3页
作者
Mueller DL;
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正文语种 eng
中图分类基础医学;
关键词
Clonal Anergy; Diacylglycerol Kinase; T-Lymphocytes; 克隆无反应性; 二酰甘油激酶;

机译：Clonal Anergy;Diacylglycerol Kinase;T-Lymphocytes;克隆无反应性;二酰甘油激酶;

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1. Linking diacylglycerol kinase to T cell anergy. [J] . Mueller DL Nature immunology . 2006,第11期

机译：将二酰基甘油激酶与T细胞无反应联系起来。
2. Inhibition of mitogen-activated protein kinase kinase blocks T cell proliferation but does not induce or prevent anergy. [J] . DeSilva DR, Jones EA, Favata MF, The Journal of Immunology: Official Journal of the American Association of Immunologists . 1998,第9期

机译：抑制有丝分裂原活化的蛋白激酶激酶可阻断T细胞增殖，但不会诱导或预防无反应。
3. Cutting edge: complement (c3d)-linked antigens break B cell anergy. [J] . Lyubchenko T, Dal-Porto JM, Holers VM, The Journal of Immunology: Official Journal of the American Association of Immunologists . 2007,第5期

机译：前沿：补体（c3d）连接的抗原破坏了B细胞的无反应性。
4. DGK and nuclear signaling nuclear diacylglycerol kinases in IIC9 cells [C] . Lisa Bregoli, Becky Tu-Sekine, Daniel M. Raben International Symposium on Regulation of Enzyme Activity and Synthesis in Normal and Neoplastic Tissues . 2003

机译：DGK和核信号核信号核二酰基甘油激酶在IIC9细胞中
5. Two leucine-rich receptor kinases mediate signaling linking cell wall biosynthesis and ACC synthase in Arabidopsis and possible downstream elements in the pathway. [D] . Xu, Shouling. 2008

机译：两种富含亮氨酸的受体激酶介导信号连接拟南芥中的细胞壁生物合成和ACC合酶以及该途径中可能的下游元件。
6. A Calcium- and Diacylglycerol-Stimulated Protein Kinase C (PKC) Caenorhabditis elegans PKC-2 Links Thermal Signals to Learned Behavior by Acting in Sensory Neurons and Intestinal Cells [O] . Marianne Land, Charles S. Rubin 2017

机译：钙和二酰基甘油刺激的蛋白激酶C（PKC）秀丽隐杆线虫PKC-2通过在感觉神经元和肠细胞中起作用将热信号链接到学习的行为
7. Glucose regulates diacylglycerol intracellular levels and protein kinase C activity by modulating diacylglycerol-kinase subcellular localization. [O] . MIELE C, PATURZO F, TEPERINO R, 2007

机译：葡萄糖通过调节二酰基甘油激酶亚细胞定位来调节二酰基甘油细胞内水平和蛋白激酶C活性。
8. B Cells from M167 Mu Kappa Transgenic Mice Fail to Proliferate after Stimulationwith Soluble Anti-Ig Antibodies. A Model for Antigen-Induced B Cell Anergy. (Reannouncement with New Availability Information) [R] . Sieckmann, D. G., Holmes, K., Hornbeck, P., 1994

机译：来自m167 mu Kappa转基因小鼠的B细胞在用可溶性抗Ig抗体刺激后不能增殖。抗原诱导B细胞无能的模型。（重新公布新的可用性信息）

Linking diacylglycerol kinase to T cell anergy.

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