Regulation of T cell receptor-alpha gene recombination by transcription

Abarrategui I; Krangel MS

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Regulation of T cell receptor-alpha gene recombination by transcription

机译：通过转录调控T细胞受体-α基因重组

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Despite the longstanding correlation between transcription and variable-(diversity)-joining (V(D)J) recombination, it is unknown whether transcription itself can direct recombinase targeting. Here we show that blockade of transcriptional elongation through the mouse T cell receptor-alpha (Tcra) locus suppressed V-alpha-to-J(alpha) recombination and chromatin remodeling of J(alpha) segments. Transcriptional blockade also derepressed cryptic J(alpha) promoters. Our results demonstrate two key functions for transcription in Tcra locus regulation. Transcription increases the recombination of J(alpha) segments located within several kilobases of a promoter and prevents the activation of downstream promoters through transcriptional interference. These influences promote an ordered progression of Tcra locus recombination events and selection of a robust Tcra repertoire.

机译：尽管转录与可变（多样性）连接（V（D）J）重组之间存在长期的相关性，但转录本身是否可以指导重组酶靶向尚不清楚。在这里，我们显示通过小鼠T细胞受体-α（Tcra）基因座的转录延伸的阻断抑制了J-α片段的V-α-to-Jα重组和染色质重塑。转录封锁也抑制了隐秘的Jα启动子。我们的结果证明了Tcra基因座调控中转录的两个关键功能。转录增加位于启动子几千个碱基内的Jα片段的重组，并通过转录干扰阻止下游启动子的激活。这些影响促进了Tcra基因座重组事件的有序发展和强大的Tcra库的选择。

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《Nature immunology》 |2006年第10期|共7页
作者
Abarrategui I; Krangel MS;
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正文语种 eng
中图分类基础医学;
关键词
RNA-POLYMERASE-II; CLASS-SWITCH RECOMBINATION; V(D)J RECOMBINATION; INTERGENIC TRANSCRIPTION; HISTONE ACETYLATION; H3 METHYLATION; BETA-GLOBIN; IN-VITRO; PROMOTER; ACCESSIBILITY;

机译：RNA聚合酶-Ⅱ;类开关重组;V（D）J重组;内转录;组氨酸乙酰化;H3甲基化;贝塔球蛋白;体外;促进剂;可及性;

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1. Regulation of T cell receptor-alpha gene recombination by transcription [J] . Abarrategui I, Krangel MS Nature immunology . 2006,第10期

机译：通过转录调控T细胞受体-α基因重组
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机译：T-box选择基因中线在腿部影像盘中的表达受转录调控和细胞谱系控制T-box选择基因中线在腿部影像盘中的表达受转录调控和细胞谱系控制腿想象盘中T-box选择基因中线的表达受转录调控和细胞谱系的控制
3. Evaluation of potential implication of membrane estrogen binding sites on ERE-dependent transcriptional activity and intracellular estrogen receptor-alpha regulation in MCF-7 breast cancer cells. [J] . Seo HS, Leclercq G The Journal of Steroid Biochemistry and Molecular Biology . 2002,第1期

机译：评估膜雌激素结合位点对MCF-7乳腺癌细胞中ERE依赖性转录活性和细胞内雌激素受体α调节的潜在影响。
4. A Bayesian Approach for Integrating Transcription Regulation and Gene Expression: Application to Saccharomyces Cerevisiae Cell Cycle Data [C] . Sudhakar Jonnalagadda, Rajagopalan Srinivasan Joint Annual RECOMB Satellite Workshop on Systems Biology and Regulatory Genomics . 2007

机译：一种贝叶斯方法，用于整合转录调节和基因表达：酿酒酵母细胞周期数据的应用
5. Transcriptional regulation of the human recombination-activating gene 2. [D] . Fong, Ivan Chek-Fuan. 2003

机译：人类重组激活基因的转录调控2。
6. The Estrogen-Regulated Transcription Factor PITX1 Coordinates Gene-Specific Regulation by Estrogen Receptor-Alpha in Breast Cancer Cells [O] . Joshua D. Stender, Fabio Stossi, Cory C. Funk, -1

机译：雌激素调节转录因子PITX1协调乳腺癌细胞中雌激素受体-α的基因特异性调节。
7. The Estrogen-Regulated Transcription Factor PITX1 Coordinates Gene-Specific Regulation by Estrogen Receptor-Alpha in Breast Cancer Cells [O] . Joshua D. Stender, Fabio Stossi, Cory C. Funk, 2011

机译：雌激素调节转录因子pitx1通过乳腺癌细胞中雌激素受体-α坐标坐标特异性调节

Regulation of T cell receptor-alpha gene recombination by transcription

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