...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature Genetics >High-density mapping of the MHC identifies a shared role for HLA-DRB1(star)01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis
【24h】

High-density mapping of the MHC identifies a shared role for HLA-DRB1(star)01:03 in inflammatory bowel diseases and heterozygous advantage in ulcerative colitis

机译：MHC的高密度作图确定了HLA-DRB1（star）01:03在炎症性肠病和溃疡性结肠炎中的杂合优势的共同作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Genome-wide association studies of the related chronic inflammatory bowel diseases (IBD) known as Crohn's disease and ulcerative colitis have shown strong evidence of association to the major histocompatibility complex (MHC). This region encodes a large number of immunological candidates, including the antigen-presenting classical human leukocyte antigen (HLA) molecules(1). Studies in IBD have indicated that multiple independent associations exist at HLA and non-HLA genes, but they have lacked the statistical power to define the architecture of association and causal alleles2,3. To address this, we performed high-density SNP typing of the MHC in >32,000 individuals with IBD, implicating multiple HLA alleles, with a primary role for HLA-DRB1*01:03 in both Crohn's disease and ulcerative colitis. Noteworthy differences were observed between these diseases, including a predominant role for class II HLA variants and heterozygous advantage observed in ulcerative colitis, suggesting an important role of the adaptive immune response in the colonic environment in the pathogenesis of IBD.
机译：全基因组关联研究涉及称为克罗恩氏病和溃疡性结肠炎的相关慢性炎症性肠病（IBD），已显示出与主要组织相容性复合体（MHC）相关的有力证据。该区域编码大量的免疫候选物，包括抗原递呈的经典人类白细胞抗原（HLA）分子（1）。 IBD的研究表明，HLA和非HLA基因存在多个独立的关联，但它们缺乏定义关联和因果等位基因结构的统计能力[2,3]。为了解决这个问题，我们在32,000多名IBD患者中进行了MHC的高密度SNP分型，涉及多个HLA等位基因，在克罗恩病和溃疡性结肠炎中HLA-DRB1 * 01：03起主要作用。在这些疾病之间观察到值得注意的差异，包括II类HLA变异的主要作用和在溃疡性结肠炎中观察到的杂合优势，这表明在结肠环境中适应性免疫应答在IBD发病机理中具有重要作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号