...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature immunology >T cell recognition of lipids: quo vadis?
【24h】

T cell recognition of lipids: quo vadis?

机译：T细胞对脂质的识别：vadis吗？

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The 4th International NKT Cell & CD1 Workshop was held 4-8 October 2006 at the Abbazia di Spineto, in the heart of Tuscany. This report highlights cutting-edge research and issues discussed at the meeting. Studies of lipid-specific T cells have identified many facets of their biology. Some features resemble those of peptide-specific T cells, whereas others are distinct and reflect the biochemical nature of recognized antigens. Like peptide-specific T cells, lipid-specific T cells also develop in the thymus and require the appropriate presentation of endogenous antigens, although the molecular mechanisms controlling their development are different. Lipid-specific T cells also recognize microbial antigens and participate in immune protection during infection, in autoimmuniry and in tumor surveillance and also direct T helper type 1 (T_H1) and T_H2 polarization. Finally, a chief population of lipid-specific T cells, which express markers of natural killer (NK) cells and therefore are known as NKT cells, has important regulatory functions that may dampen or exacerbate inflammatory responses. These issues were discussed at the '4th International NKT Cell & CD1 Workshop' at the Abbazia di Spineto in Tuscany.
机译：第四届国际NKT细胞和CD1国际研讨会于2006年10月4日至8日在托斯卡纳心脏地带的Abbazia di Spineto举行。本报告重点介绍了会议上讨论的前沿研究和问题。脂质特异性T细胞的研究已经确定了其生物学的许多方面。一些特征类似于肽特异性T细胞的特征，而其他特征则不同并且反映了公认抗原的生化性质。像肽特异性T细胞一样，脂质特异性T细胞也在胸腺中发育，并需要适当呈递内源性抗原，尽管控制其发育的分子机制是不同的。脂质特异性T细胞还识别微生物抗原，并在感染过程中，自身免疫和肿瘤监测中参与免疫保护，并直接指导1型T辅助细胞（T_H1）和T_H2极化。最后，主要的脂类特异性T细胞群具有表达自然杀伤（NK）细胞的标志物，因此被称为NKT细胞，它们具有重要的调节功能，可以减弱或加剧炎症反应。在托斯卡纳的Abbazia di Spineto举行的“第四届国际NKT细胞和CD1国际研讨会”上讨论了这些问题。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号