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首页> 外文期刊>Nature immunology >Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.
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Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation.

机译：为了抑制功能和抑制效应子分化，需要在调节性T细胞中抑制基因组组织者SATB1。

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摘要

Regulatory T cells (T(reg) cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of T(reg) cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3' untranslated region. Release of SATB1 from the control of Foxp3 in T(reg) cells caused loss of suppressive function, establishment of transcriptional T(eff) cell programs and induction of T(eff) cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining T(reg) cell functionality.
机译：调节性T细胞（T（reg）细胞）对于自我耐受和免疫稳态至关重要。缺乏效应T细胞（T（eff）细胞）功能和由T（reg）细胞获得的抑制活性取决于Foxp3诱导的转录程序。在这里我们报告说，抑制SATB1，调节染色质结构和基因表达的基因组组织者，对于T（reg）细胞的表型和功能至关重要。作为转录阻遏物的Foxp3直接抑制了SATB1基因座，并通过诱导结合了SATB1 3'非翻译区的microRNA间接抑制了它。从T（reg）细胞中Foxp3的控制释放SATB1导致抑制功能丧失，转录T（eff）细胞程序的建立和T（eff）细胞因子的诱导。我们的数据支持以下建议：抑制SATB1介导的全球染色质重塑调控对于维持T（reg）细胞功能至关重要。

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