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MicroRNAs as mediators of viral evasion of the immune system

机译：MicroRNA作为免疫系统病毒逃逸的媒介

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摘要

Cellular microRNAs serve key roles in the post-transcriptional regulation of almost every cellular gene-regulatory pathway, and it therefore is not surprising that viruses have found ways to subvert this process. Several viruses encode microRNAs that directly downregulate the expression of factors of the innate immune system, including proteins involved in promoting apoptosis and recruiting effector cells of the immune system. Viruses have also evolved the ability to downregulate or upregulate the expression of specific cellular miRNAs to enhance their replication. This Review provides an overview of the present knowledge of the complex interactions of viruses with the microRNA machinery of cells.
机译：细胞微RNA在几乎所有细胞基因调控途径的转录后调控中起着关键作用，因此，病毒找到了颠覆这一过程的方法也就不足为奇了。几种病毒编码直接下调先天免疫系统因子表达的microRNA，包括与促进免疫细胞凋亡和募集效应细胞有关的蛋白质。病毒还发展了下调或上调特定细胞miRNA表达以增强其复制的能力。这篇综述概述了病毒与细胞microRNA机制之间复杂相互作用的当前知识。

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