首页> 外文期刊>Nature immunology >Regulation unmasked by activation
【24h】

Regulation unmasked by activation

机译:激活不掩盖法规

获取原文
获取原文并翻译 | 示例
           

摘要

Despite the widespread clinical use of antibodies that target the glycosylphos-phatidylinositol (GPI)-anchored glycoprotein CD52, little is known about its function. In this issue of Nature Immunology, Bandala-Sanchez et al. provide evidence that the lectin Siglec-10 is a receptor for soluble human CD52 (ref. 1). Soluble CD52 is released in a phospholipase C-dependent manner from a population of CD4+ T cells with high expression of CD52; it then binds to Siglec-10 on activated T cells, which results in inhibition of their function.
机译:尽管靶向糖基磷酰肌醇(GPI)锚定的糖蛋白CD52的抗体在临床上得到了广泛使用,但对其功能知之甚少。在本期《自然免疫学》中,Bandala-Sanchez等人。提供的证据表明,凝集素Siglec-10是可溶性人类CD52的受体(参考文献1)。可溶性CD52以磷脂酶C依赖性的方式从高表达CD52的CD4 + T细胞群体中释放出来。然后与活化的T细胞上的Siglec-10结合,从而抑制其功能。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号