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Sterol regulatory element-binding proteins are essential for the metabolic programming of effector T cells and adaptive immunity

机译：甾醇调节元件结合蛋白对于效应T细胞的代谢编程和适应性免疫至关重要

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摘要

Newly activated CD8+ T cells reprogram their metabolism to meet the extraordinary biosynthetic demands of clonal expansion; however, the signals that mediate metabolic reprogramming remain poorly defined. Here we demonstrate an essential role for sterol regulatory element-binding proteins (SREBPs) in the acquisition of effector-cell metabolism. Without SREBP signaling, CD8 + T cells were unable to blast, which resulted in attenuated clonal expansion during viral infection. Mechanistic studies indicated that SREBPs were essential for meeting the heightened lipid requirements of membrane synthesis during blastogenesis. SREBPs were dispensable for homeostatic proliferation, which indicated a context-specific requirement for SREBPs in effector responses. Our studies provide insights into the molecular signals that underlie the metabolic reprogramming of CD8+ T cells during the transition from quiescence to activation.
机译：新激活的CD8 + T细胞重新编程其代谢，以满足克隆扩增的非凡生物合成需求;然而，介导代谢重编程的信号仍然不清楚。在这里，我们证明了固醇调节元件结合蛋白（SREBPs）在效应细胞代谢的获取中的重要作用。没有SREBP信号传导，CD8 + T细胞无法爆炸，从而导致病毒感染期间克隆扩增减弱。机理研究表明，SREBPs对于在成胚过程中满足膜合成对脂质增加的需求至关重要。 SREBP对于稳态增殖是必不可少的，这表明在效应反应中对SREBP的上下文特定要求。我们的研究提供了从静止到激活过渡过程中CD8 + T细胞代谢重编程基础的分子信号的见解。

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