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首页> 外文期刊>Nature immunology >Enhanced survival of lung tissue-resident memory CD8 + T cells during infection with influenza virus due to selective expression of IFITM3
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Enhanced survival of lung tissue-resident memory CD8 + T cells during infection with influenza virus due to selective expression of IFITM3

机译：由于IFITM3的选择性表达，在流感病毒感染期间提高了肺组织驻留记忆CD8 + T细胞的存活率

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摘要

Infection with influenza virus results in the deposition of anti-influenza CD8 + resident memory T cells (T RM cells) in the lung. As a consequence of their location in the lung mucosal tissue, these cells are exposed to cytopathic pathogens over the life of the organism and may themselves be susceptible to infection. Here we found that lung T RM cells selectively maintained expression of the interferon-induced transmembrane protein IFITM3, a protein that confers broad resistance to viral infection. Lung T RM cells that lacked IFITM3 expression were more susceptible to infection than were their normal counterparts and were selectively lost during a secondary bout of infection. Thus, lung T RM cells were programmed to retain IFITM3 expression, which facilitated their survival and protection from viral infection during subsequent exposures.
机译：感染流感病毒会导致抗流感CD8 +驻留记忆T细胞（T RM细胞）在肺部沉积。由于它们在肺粘膜组织中的定位，这些细胞在生物体的整个生命周期中都暴露于细胞致病性病原体中，并且自身可能易于感染。在这里，我们发现肺TRM细胞选择性地维持了干扰素诱导的跨膜蛋白IFITM3的表达，该蛋白赋予病毒感染广泛的抵抗力。缺乏IFITM3表达的肺T RM细胞比正常人更容易感染，并且在继发感染后选择性丢失。因此，肺T RM细胞被编程为保留IFITM3表达，这有助于它们的生存和在随后的暴露过程中免受病毒感染。

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