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A DRAM-atic end for T cells

机译:T细胞的DRAMatic端

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Infection of CD4+ T cells with human immunodeficiency virus (HIV) can result in a caspase-independent cell-death pathway, but the details of this process remain unclear. In PLoS Pathogens, Estaquier and colleagues link the autophagy-regulatory protein DRAM to HIV-triggered death of CD4+ T cells. Infection of T cells with HIV induces DRAM expression in a manner dependent on the tumor suppressor p53 and subsequent activation of autophagy and cell death. However, autophagy is not critical for cell death; instead, after infection with HIV, DRAM associates with lysosomes and initiates destabilization of their membranes-a classic cell-intrinsic death initiator. How DRAM actually disrupts lysosomal membranes is unclear, but the cell death that results from DRAM activity substantially impairs viral infection. DRAM-mediated killing may therefore represent a cell-intrinsic mechanism for eliminating virus-infected cells.
机译:CD4 + T细胞感染人免疫缺陷病毒(HIV)可能导致caspase依赖性细胞死亡途径,但该过程的细节仍不清楚。在PLoS病原体中,Estaquier及其同事将自噬调节蛋白DRAM与HIV触发的CD4 + T细胞死亡联系起来。用HIV感染T细胞以依赖于肿瘤抑制因子p53以及随后的自噬激活和细胞死亡的方式诱导DRAM表达。然而,自噬对于细胞死亡并不重要。相反,在感染了HIV后,DRAM与溶酶体结合并引发其膜的失稳-一种经典的细胞内在死亡引发剂。 DRAM如何真正破坏溶酶体膜尚不清楚,但DRAM活性导致的细胞死亡大大损害了病毒感染。因此,DRAM介导的杀伤作用可能代表了消除病毒感染细胞的细胞内在机制。

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