GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling

WangY.; MisumiI.; GuA.-D.; CurtisT.A.; SuL.; WhitmireJ.K.; WanY.Y.

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GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling

机译：GATA-3控制着TCR和细胞因子信号传导下游T细胞的维持和增殖

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GATA-3 controls T helper type 2 (TH2) differentiation. However, whether GATA-3 regulates the function of mature T cells beyond TH2 determination remains poorly understood. We found that signaling via the T cell antigen receptor (TCR) and cytokine stimulation promoted GATA-3 expression in CD8 + T cells, which controlled cell proliferation. Although GATA-3-deficient CD8 + T cells were generated, their peripheral maintenance was impaired, with lower expression of the receptor for interleukin 7 (IL-7R). GATA-3-deficient T cells had defective responses to viral infection and alloantigen. The proto-oncoprotein c-Myc was a critical target of GATA-3 in promoting T cell proliferation. Our study thus demonstrates an essential role for GATA-3 in controlling the maintenance and proliferation of T cells and provides insight into immunoregulation.

机译：GATA-3控制2型T辅助细胞（TH2）的分化。但是，GATA-3是否能调节TH2以外的成熟T细胞的功能仍然知之甚少。我们发现通过T细胞抗原受体（TCR）和细胞因子刺激的信号传导促进了CD8 + T细胞中GATA-3的表达，从而控制了细胞的增殖。尽管生成了GATA-3缺陷型CD8 + T细胞，但其外周维持功能受损，白介素7（IL-7R）受体的表达降低。 GATA-3缺陷型T细胞对病毒感染和同种抗原的反应有缺陷。原癌蛋白c-Myc是GATA-3促进T细胞增殖的关键靶标。因此，我们的研究证明了GATA-3在控制T细胞维持和增殖中的重要作用，并为免疫调节提供了见识。

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《Nature immunology》 |2013年第7期|共9页
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WangY.; MisumiI.; GuA.-D.; CurtisT.A.; SuL.; WhitmireJ.K.; WanY.Y.;
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正文语种 eng
中图分类医学免疫学;
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1. GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling [J] . WangY., MisumiI., GuA.-D., Nature immunology . 2013,第7期

机译：GATA-3控制着TCR和细胞因子信号传导下游T细胞的维持和增殖
2. Distinct TCR signaling pathways drive proliferation and cytokine production in T cells [J] . GuyC.S., VignaliK.M., TemirovJ., Nature immunology . 2013,第3期

机译：独特的TCR信号通路驱动T细胞增殖和细胞因子产生
3. D-type cyclins are important downstream effectors of cytokine signaling that regulate the proliferation of normal and neoplastic mammary epithelial cells [J] . ZhangQ., SakamotoK., WagnerK.-U. Molecular and Cellular Endocrinology . 2014,第1期

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7. GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling [O] . Yunqi Wang, Ichiro Misumi, Ai-Di Gu, 2013

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GATA-3 controls the maintenance and proliferation of T cells downstream of TCR and cytokine signaling

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