The immunology of asthma

Lambrecht Bart N.; Hammad Hamida

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The immunology of asthma

机译：哮喘的免疫学

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Asthma is a common disease that affects 300 million people worldwide. Given the large number of eosinophils in the airways of people with mild asthma, and verified by data from murine models, asthma was long considered the hallmark T helper type 2 (T(H)2) disease of the airways. It is now known that some asthmatic inflammation is neutrophilic, controlled by the T(H)17 subset of helper T cells, and that some eosinophilic inflammation is controlled by type 2 innate lymphoid cells (ILC2 cells) acting together with basophils. Here we discuss results from in-depth molecular studies of mouse models in light of the results from the first clinical trials targeting key cytokines in humans and describe the extraordinary heterogeneity of asthma.

机译：哮喘是一种常见疾病，全世界有3亿人受其影响。鉴于轻度哮喘患者气道中存在大量嗜酸性粒细胞，并已通过鼠类模型数据进行验证，哮喘长期以来被认为是气道2型T辅助性（T（H）2）标志性疾病。现在已知，一些哮喘炎症是嗜中性的，由辅助T细胞的T（H）17亚群控制，某些嗜酸性炎症是由与嗜碱性粒细胞一起起作用的2型先天性淋巴样细胞（ILC2细胞）控制的。在这里，我们根据针对人类关键细胞因子的首批临床试验的结果，对小鼠模型进行深入分子研究的结果，并描述了哮喘的非均质性。

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《Nature immunology》 |2015年第1期|共12页
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Lambrecht Bart N.; Hammad Hamida;
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中图分类医学免疫学;
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The immunology of asthma

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