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首页> 外文期刊>Nature immunology >Germinal center B and follicular helper T cells: siblings, cousins or just good friends?
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Germinal center B and follicular helper T cells: siblings, cousins or just good friends?

机译：生殖中心B和滤泡辅助性T细胞：兄弟姐妹，堂兄还是好朋友？

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摘要

Humoral immunity requires interaction between specialized populations of B cells and CD4~+ T cells, called follicular helper T cells (T_(FH) cells), in the germinal center (GC) to produce memory B cells and long-lived plasma cells. Molecular crosstalk between GC B cells and T_(FH) cells influences the survival, proliferation and differentiation of each cell type. This pairing of GC B cells and T_(FH) cells also occurs at the transcriptional level as the Bcl-6-IRF4-Blimp-l axis, which is crucial for B cell differentiation, is also essential for the T_(FH) cell identity. Less is known about the memory B cells that arise from the GC pool, as they seem to be distinctly 'programmed' on the basis of their antigen receptor affinity to enter the long-lived memory pool.
机译：体液免疫要求在生发中心（GC）的B细胞和CD4〜+ T细胞（称为卵泡辅助性T细胞（T_（FH）细胞））的特定种群之间相互作用，以产生记忆B细胞和长寿浆细胞。 GC B细胞与T_（FH）细胞之间的分子串扰影响每种细胞类型的存活，增殖和分化。 GC B细胞和T_（FH）细胞的这种配对也发生在转录水平上，因为Bcl-6-IRF4-Blimp-1轴对于B细胞的分化至关重要，对于T_（FH）细胞的特性也至关重要。对于从GC池中产生的记忆B细胞知之甚少，因为它们似乎根据其抗原受体亲和力进入了长寿的记忆池而被明确地“编程”了。

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