...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature immunology >Mast cell-DC axis
【24h】

Mast cell-DC axis

机译：肥大细胞-DC轴

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Malaria continues to pose a considerable global health threat; hence, understanding the immune response to plasmodia is of utmost importance. In Nature Medicine, Guermonprez et al. describe a mast cell-dendritic cell (DC) axis associated with plasmodia infection. Infection of mice with Plasmodium chabaudi leads to release of the cytokine Flt3L from mast cells, which substantially increases the number of CD8a+ DCs and, in turn, activates CD8+ T cells. The authors trace those effects to higher expression of xanthine dehydrogenase in a yet-to-be identified radiosensitive cell population. That population responds to type I interferons produced during infection. Plasmodia-infected erythrocytes release hypoxanthine, which then can be converted to uric acid by xanthine dehydrogenase. Uric acid triggers mast cell degranulation and cleavage of membrane-tethered Flt3L. A similar response occurs in human patients with malaria, which suggests that this innate response to plasmodia is conserved.
机译：疟疾继续对全球健康构成严重威胁;因此，了解对疟原虫的免疫反应至关重要。在自然医学中，Guermonprez等人。描述了与疟原虫感染相关的肥大细胞树突状细胞（DC）轴。 Chabaudi疟原虫感染小鼠会导致肥大细胞释放细胞因子Flt3L，从而大大增加CD8a + DC的数量，进而激活CD8 + T细胞。作者将这些效应归因于尚未确定的放射敏感性细胞群中黄嘌呤脱氢酶的更高表达。该人群对感染期间产生的I型干扰素有反应。被疟原虫感染的红细胞释放次黄嘌呤，然后可以通过黄嘌呤脱氢酶将其转变为尿酸。尿酸触发肥大细胞脱粒和膜拴Flt3L的裂解。在人类疟疾患者中也会发生类似的反应，这表明这种对疟原虫的先天反应是保守的。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号