Vaccines that stimulate T cell immunity to HIV-1: The next step

McmichaelA.J.; KoffW.C.

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Vaccines that stimulate T cell immunity to HIV-1: The next step

机译：刺激T细胞对HIV-1免疫的疫苗：下一步

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The search for a vaccine against human immunodeficiency virus type 1 (HIV-1) has many hurdles to overcome. Ideally, the stimulation of both broadly neutralizing antibodies and cell-mediated immune responses remains the best option, but no candidate in clinical trials at present has elicited such antibodies, and efficacy trials have not demonstrated any benefit for vaccines designed to stimulate immune responses of CD8 + T cells. Findings obtained with the simian immunodeficiency virus (SIV) monkey model have provided new evidence that stimulating effective CD8 + T cell immunity could provide protection, and in this Perspective we explore the path forward for optimizing such responses in humans.

机译：寻找针对人类1型免疫缺陷病毒（HIV-1）的疫苗有许多障碍需要克服。理想情况下，同时刺激广泛中和的抗体和细胞介导的免疫反应仍然是最佳选择，但目前尚无临床试验的候选物引发此类抗体，并且功效试验尚未证明设计刺激CD8免疫反应的疫苗有任何益处+ T细胞。猿猴免疫缺陷病毒（SIV）猴模型获得的发现提供了新的证据，证明有效的CD8 + T细胞免疫力可以提供保护，因此在此观点中，我们探索了在人类中优化此类反应的途径。

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《Nature immunology》 |2014年第4期|共4页
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McmichaelA.J.; KoffW.C.;
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正文语种 eng
中图分类医学免疫学;
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1. Vaccines that stimulate T cell immunity to HIV-1: The next step [J] . McmichaelA.J., KoffW.C. Nature immunology . 2014,第4期

机译：刺激T细胞对HIV-1免疫的疫苗：下一步
2. An Ad5-vectored HIV-1 vaccine elicits cell-mediated immunity but does not affect disease progression in HIV-1-infected male subjects: results from a randomized placebo-controlled trial (the Step study). [J] . Fitzgerald DW, Janes H, Robertson M, The Journal of Infectious Diseases . 2011,第6期

机译：用Ad5介导的HIV-1疫苗可引发细胞介导的免疫，但不影响感染HIV-1的男性受试者的疾病进展：一项来自随机安慰剂对照试验的结果（该步骤研究）。
3. Efficacy assessment of a cell-mediated immunity HIV-1 vaccine (the Step Study): a double-blind, randomised, placebo-controlled, test-of-concept trial. [J] . Buchbinder SP, Mehrotra DV, Duerr A, The Lancet . 2008,第9653期

机译：细胞介导的HIV-1疫苗免疫效果评估（分步研究）：一项双盲，随机，安慰剂对照，概念测试的试验。
4. EFFECT OF AGE AND VACCINE INDUCED IMMUNE STIMULATION ON PCV2 INFECTION [C] . T Opriessnig, PG Halbur, F Pallares, Congress of the International Pig Veterinary Society . 2002

机译：年龄和疫苗诱导免疫刺激对PCV2感染的影响
5. Induction of strong cellular immune responses in the gut mucosa against HIV-1 using a combination vaccine of recombinant Clostridium perfringens and HIV-1 virus like particles. [D] . Poonam, Poonam. 2009

机译：使用重组产气荚膜梭状芽孢杆菌和HIV-1病毒样颗粒的组合疫苗在肠道粘膜中诱导针对HIV-1的强细胞免疫反应。
6. Vaccines that stimulate T cell immunity to HIV-1: the next step [O] . Andrew J McMichael, Wayne C Koff -1

机译：刺激T细胞对HIV-1免疫的疫苗：下一步
7. Vaccines that stimulate T cell immunity to HIV-1: the next step. [O] . Mcmichael, AJ, Koff, WC 2014

机译：刺激T细胞对HIV-1免疫的疫苗：下一步。

Vaccines that stimulate T cell immunity to HIV-1: The next step

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