The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

Woong-Kyung Suh; Beata U Gajewska; Hitoshi Okada; Matthew A Gronski; Edward M Bertram; Wojciech Dawicki; Gordon S Duncan; Jacob Bukczynski; Suzanne Plyte; Andrew Elia

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The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

机译：B7家族成员B7-H3优先下调T辅助1型介导的免疫反应

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We investigated the in vivo function of the B7 family member B7-H3 (also known as B7RP-2) by gene targeting. B7-H3 inhibited T cell proliferation mediated by antibody to T cell receptor or allogeneic antigen-presenting cells. B7-H3-deficient mice developed more severe airway inflammation than did wild-type mice in conditions in which T helper cells differentiated toward type 1 (T_H1) rather than type 2 (T_H 2). B7-H3 expression was consistently enhanced by interferon-γ but suppressed by interleukin 4 in dendritic cells. B7-H3-deficient mice developed experimental autoimmune encephalomyelitis several days earlier than their wild-type littermates, and accumulated higher concentrations of autoantibodies to DNA. Thus, B7-H3 is negative regulatory that preferentially affects T_H1 responses.

机译：我们通过基因靶向研究了B7家族成员B7-H3（也称为B7RP-2）的体内功能。 B7-H3抑制了由针对T细胞受体或同种异体抗原呈递细胞的抗体介导的T细胞增殖。在T辅助细胞向1型（T_H1）而非2型（T_H 2）分化的条件下，B7-H3缺陷型小鼠比野生型小鼠更严重的呼吸道炎症。在树突状细胞中，B7-H3的表达一直被干扰素-γ增强，但被白介素4抑制。缺乏B7-H3的小鼠比其野生型同窝小鼠早几天发展了实验性自身免疫性脑脊髓炎，并积累了更高浓度的DNA自身抗体。因此，B7-H3是负调节剂，优先影响T_H1响应。

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《Nature immunology》 |2003年第9期|共8页
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Woong-Kyung Suh; Beata U Gajewska; Hitoshi Okada; Matthew A Gronski; Edward M Bertram; Wojciech Dawicki; Gordon S Duncan; Jacob Bukczynski; Suzanne Plyte; Andrew Elia;
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1. The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses [J] . Woong-Kyung Suh, Beata U Gajewska, Hitoshi Okada, Nature immunology . 2003,第9期

机译：B7家族成员B7-H3优先下调T辅助1型介导的免疫反应
2. Placental growth factor down-regulates type 1 T helper immune response by modulating the function of dendritic cells. [J] . Lin YL, Liang YC, Chiang BL Journal of Leukocyte Biology: An Official Publication of the Reticuloendothelial Society . 2007,第6期

机译：胎盘生长因子通过调节树突状细胞的功能来下调1型T辅助免疫反应。
3. Resting Respiratory Tract Dendritic Cells Preferentially Stimulate T Helper Cell Type 2 (Th2) Responses and Require Obligatory Cytokine Signals for Induction of Th1 Immunity [J] . Philip A. Stumbles, Jennifer A. Thomas, Carolyn L. Pimm, The Journal of Experomental Medicine . 1998,第11期

机译：休息的呼吸道树突状细胞优先刺激2型T辅助细胞反应，并需要强制性细胞因子信号诱导Th1免疫。
4. Th2-type innate immune responses mediated by natural helper cells [C] . Shigeo Koyasu, Kazuyo Moro Federation of Immunological Societies of Asia-Oceania. . 2013

机译：天然辅助细胞介导的Th2型先天免疫应答
5. Functional analysis of CD28/B7 and CD40/CD40L costimulation during the in vivo type 2 immune response. [D] . Lu, Pin. 1996

机译：在体内2型免疫应答过程中CD28 / B7和CD40 / CD40L共刺激的功能分析。
6. Interferon-λ1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro [O] . Shekar Srinivas, Jihong Dai, Joyce Eskdale, 2008

机译：干扰素-λ1（interleukin-29）在体外比其他T辅助2型细胞因子反应优先下调白介素13
7. Interferon-λ1 (interleukin-29) preferentially down-regulates interleukin-13 over other T helper type 2 cytokine responses in vitro [O] . Srinivas, Shekar, Dai, Jihong, Eskdale, Joyce, 2008

机译：干扰素-λ1（interleukin-29）在体外比其他T辅助2型细胞因子反应优先下调白介素13
8. Establishment of an Inbred Line of Mice that Express a Synergistic Immune Detect Precluding In Vitro Responses to Type 1 and Type 2 Antigens, B Cell Mitogens, and a Number of T Cell-Derived helper Factors [R] . Mond, J. J., Norton, G., Paul, W. E., 1983

机译：建立表达协同免疫检测的小鼠近交系，预防1型和2型抗原，B细胞mitogens和一些T细胞衍生辅助因子的体外反应

The B7 family member B7-H3 preferentially down-regulates T helper type 1-mediated immune responses

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