In vivo Injected Mitochondria-Targeted PlastoquinoneAntioxidant SkQR1 Prevents β-Amyloid-Induced Decayof Long-Term Potentiation in Rat Hippocampal Slices

N. A. Kapay; N. K. Isaev; E. V. Stelmashook

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In vivo Injected Mitochondria-Targeted PlastoquinoneAntioxidant SkQR1 Prevents β-Amyloid-Induced Decayof Long-Term Potentiation in Rat Hippocampal Slices

机译：体内注射线粒体靶向的醌醌抗氧化剂SkQR1防止β-淀粉样蛋白诱导的大鼠海马切片长期增生衰减。

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Addition of 200 nM β-amyloid 1-42 (Abeta) to a rat hippocampal slice impairs the induction of a long-term post-tetanic potentiation (LTP) of population spike (PS) in pyramidal neurons of the CA1 field of hippocampus. Intraperitoneal injection into the rat of the mitochondria-targeted plastoquinone derivative SkQRl (1 umol/kg of weight given 24 h before the slices were made) abolishes the deleterious effect of Abeta on LTP. These data demonstrate that SkQRl therapy is able to compensate the Abeta-induced impairments of long-term synaptic plasticity in the hippocampus, which are the main cause of loss of memory and other cognitive functions associated with Alzheimer's disease.

机译：向大鼠海马切片中添加200 nMβ-淀粉样蛋白1-42（Abeta）会削弱海马CA1区域锥体神经元中种群峰值（PS）的长期强直后增强（LTP）诱导能力。向大鼠腹膜内注射线粒体定位的质体醌衍生物SkQR1（在切片前24小时给予1 umol / kg体重）消除了Abeta对LTP的有害作用。这些数据表明，SkQR1疗法能够补偿Abeta引起的海马的长期突触可塑性损伤，这是记忆丧失和与阿尔茨海默氏病有关的其他认知功能的主要原因。

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《Biochemistry》 |2011年第12期|共4页
作者
N. A. Kapay; N. K. Isaev; E. V. Stelmashook;
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正文语种 eng
中图分类生物化学;
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Alzheimer's disease; β-amyloid; long-term memory; long-term potentiation; neurons; hippocampus; mitochondria-targeted antioxidants; SkQR1;

机译：阿尔茨海默病;β-淀粉样蛋白;长期记忆;长期增强;神经元;海马;线粒体靶向抗氧化剂;SkQR1;

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1. In vivo Injected Mitochondria-Targeted PlastoquinoneAntioxidant SkQR1 Prevents β-Amyloid-Induced Decayof Long-Term Potentiation in Rat Hippocampal Slices [J] . N. A. Kapay, N. K. Isaev, E. V. Stelmashook Biochemistry . 2011,第12期

机译：体内注射线粒体靶向的醌醌抗氧化剂SkQR1防止β-淀粉样蛋白诱导的大鼠海马切片长期增生衰减。
2. Mitochondria-targeted plastoquinone antioxidant SkQ1 prevents amyloid-β-induced impairment of long-term potentiation in rat hippocampal slices [J] . KapayN.A., PopovaO.V., IsaevN.K., Journal of Alzheimer's disease: JAD . 2013,第2期

机译：线粒体靶向质体醌抗氧化剂SkQ1防止淀粉样β诱导的大鼠海马切片长期增强功能受损
3. Intraneuronally injected amyloid beta inhibits long-term potentiation in rat hippocampal slices [J] . NomuraI., TakechiH., KatoN. Journal of Neurophysiology . 2012,第5期

机译：神经内注射淀粉样蛋白β抑制大鼠海马切片的长期增强
4. Theta activity during a long-term potentiation of the hippocampal field CA/sub 1/ and some model notions of the septo-hippocampal complex work [C] . Rezvova, B.R., Frolov, . 1995

机译：海马区CA / sub 1 /的长期增强过程中的theta活性以及隔垫-海马复合体工作的一些模型概念
5. Norepinephrine-induced potentiation is not blocked by the local diffusion of the NMDA channel blocker, ketamine, at concentrations that prevent tetanically-induced long-term potentiation in the dentate gyrus in vivo. [D] . Frizzell, Lynn Marie. 1994

机译：去甲肾上腺素诱导的增强作用不会被NMDA通道阻滞剂氯胺酮的局部扩散所阻断，其浓度可防止在体内齿状回中由强直性诱导的长期增强作用。
6. Inhibition of calpain prevents NMDA-induced cell death and β-amyloid-induced synaptic dysfunction in hippocampal slice cultures [O] . V Nimmrich, KG Reymann, M Strassburger, 2010

机译：抑制钙蛋白酶防止海马切片培养物中NMDA诱导的细胞死亡和β-淀粉样蛋白引起的突触功能障碍。
7. Inhibition of calpain prevents NMDA-induced cell death and β-amyloid-induced synaptic dysfunction in hippocampal slice cultures [O] . Nimmrich, V, Reymann, KG, Strassburger, M, 2010

机译：抑制钙蛋白酶防止海马切片培养物中NMDA诱导的细胞死亡和β-淀粉样蛋白引起的突触功能障碍。
8. Role of Protein Synthesis and Monoamines in the Production of Long-Term Potentiation in the Rat Hippocampal Slice. [R] . Stanton, P. K. 1985

机译：蛋白质合成和单胺类在大鼠海马脑片长时程增强中的作用。

In vivo Injected Mitochondria-Targeted PlastoquinoneAntioxidant SkQR1 Prevents β-Amyloid-Induced Decayof Long-Term Potentiation in Rat Hippocampal Slices

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