Lymphocyte calcium signaling from membrane to nucleus

Gallo EM; Cante-Barrett K; Crabtree GR; Crabtree GR

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Lymphocyte calcium signaling from membrane to nucleus

机译：淋巴细胞钙从膜到核的信号传导

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Ca2+ signals control a variety of lymphocyte responses, ranging from short-term cytoskeletal modifications to long-term changes in gene expression. The identification of molecules and channels that modulate Ca2+ entry into T and B lymphocytes has both provided details of the molecular events leading to immune responses and raised controversy. Here we review studies of the pathways that allow Ca2+ entry, the function of Ca2+ in the regulation of cell polarity and motility and the principles by which Ca2+-dependent transcription regulates lymphocyte function.

机译：Ca2 +信号控制着各种各样的淋巴细胞反应，从短期的细胞骨架修饰到基因表达的长期改变。对调节Ca2 +进入T和B淋巴细胞的分子和通道的鉴定，都提供了导致免疫反应和引发争议的分子事件的详细信息。在这里，我们回顾了允许Ca2 +进入的途径，Ca2 +在调节细胞极性和运动性中的功能以及Ca2 +依赖性转录调节淋巴细胞功能的原理的研究。

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《Nature immunology》 |2006年第1期|共8页
作者
Gallo EM; Cante-Barrett K; Crabtree GR; Crabtree GR;
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正文语种 eng
中图分类基础医学;
关键词
T-CELL-ACTIVATION; DEPENDENT PROTEIN-KINASE; ALDRICH-SYNDROME PROTEIN; NONSELECTIVE CATION CHANNEL; MICROTUBULE-ORGANIZING CENTER; PERIPHERAL-BLOOD LYMPHOCYTES; GLYCOGEN-SYNTHASE KINASE-3; CD28 COSTIMULATORY SIGNAL; ANTIGEN RECEPTOR; IMMUNOLOGICAL SYNAPSE;

机译：T细胞活化;相关蛋白激酶;ALDRICH SYNDROME蛋白;非选择性阳离子通道;微管组织中心;外周血淋巴细胞;糖原合酶3;CD28刺激性信号;抗信号;

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1. Lymphocyte calcium signaling from membrane to nucleus [J] . Gallo EM, Cante-Barrett K, Crabtree GR, Nature immunology . 2006,第1期

机译：淋巴细胞钙从膜到核的信号传导
2. Fluoxetine suppresses calcium signaling in human T lymphocytes through depletion of intracellular calcium stores [J] . Gobin V., De Bock M., Broeckx B. J. G., Cell Calcium: The International Interdisciplinary Forum for Research on Calcium . 2015,第3期

机译：氟西汀通过消耗细胞内钙存储抑制人T淋巴细胞中的钙信号传导
3. Apoptosis of Antigen-Specific T Lymphocytes upon the Engagement of CD8 by Soluble HLA Class I Molecules Is Fas Ligand/Fas Mediated: Evidence for the Involvement of p56lck, Calcium Calmodulin Kinase II, and Calcium-Independent Protein Kinase C Signaling Pathways and for NF-κB and NF-AT Nuclear Translocation [J] . Paola Contini, Massimo Ghio, Andrea Merlo, The journal of immunology . 2005,第11期

机译：Fas配体/ Fas介导了可溶性HLA I类分子与CD8结合后抗原特异性T淋巴细胞的凋亡：p56lck，钙调蛋白激酶II和钙独立蛋白激酶C信号通路以及NF-涉及的证据κB和NF-AT核易位
4. The signal transduction cascade in lymphocytes during 60 Hz magnetic field exposures: calcium influx, Ca/sup +2//sub i/, pH/sub i/ and c-MYC mRNA [C] . Liburdy, R.P., Callahan, . 1993

机译：60 Hz磁场暴露期间淋巴细胞中的信号转导级联反应：钙内流，Ca / sup +2 / / sub i /，pH / sub i /和c-MYC mRNA
5. Early responses to oxidative stress in heart cells: Signals from the cell membrane to the nucleus and beyond [D] . Purdom-Dickinson, Sally Elizabeth 2005

机译：对心脏细胞氧化应激的早期反应：从细胞膜到细胞核及其他细胞的信号
6. The IQD Family of Calmodulin-Binding Proteins Links Calcium Signaling to Microtubules Membrane Subdomains and the Nucleus [O] . Katharina Bürstenbinder, Birgit Möller, Romina Plötner, 2017

机译：钙调蛋白结合蛋白的IQD家族将钙信号连接到微管膜亚域和细胞核。
7. The IQD Family of Calmodulin-Binding Proteins Links Calcium Signaling to Microtubules, Membrane Subdomains, and the Nucleus [O] . Katharina Bürstenbinder, Birgit Möller, Romina Plötner, 2017

机译：钙调蛋白结合蛋白的IQD系列将钙信号传导至微管，膜亚域和核
8. Neuromodulation of Ion Channels and Calcium Signaling in T Lymphocytes [R] . Cahalan, M. 1988

机译：T淋巴细胞中离子通道的神经调节和钙信号转导

Lymphocyte calcium signaling from membrane to nucleus

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