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首页> 外文期刊>Nature immunology >Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor
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Natural killer cell trafficking in vivo requires a dedicated sphingosine 1-phosphate receptor

机译：体内自然杀伤细胞的运输需要专门的鞘氨醇1-磷酸受体

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摘要

Consistent with their function in immune surveillance, natural killer (NK) cells are distributed throughout lymphoid and nonlymphoid tissues. However, the mechanisms governing the steady-state trafficking of NK cells remain unknown. The lysophospholipid sphingosine 1-phosphate (S1P), by binding to its receptor S1P(1), regulates the recirculation of T and B lymphocytes. In contrast, S1P(5) is detected in the brain and regulates oligodendrocyte migration and survival in vitro. Here we show that S1P(5) was also expressed in NK cells in mice and humans and that S1P(5)- deficient mice had aberrant NK cell homing during steady-state conditions. In addition, we found that S1P(5) was required for the mobilization of NK cells to inflamed organs. Our data emphasize distinct mechanisms regulating the circulation of various lymphocyte subsets and raise the possibility that NK cell trafficking may be manipulated by therapies specifically targeting S1P(5).
机译：与它们在免疫监视中的功能一致，自然杀伤（NK）细胞分布在整个淋巴组织和非淋巴组织中。但是，控制NK细胞稳态运输的机制仍然未知。溶血磷脂酰鞘氨醇1-磷酸（S1P）通过结合其受体S1P（1）来调节T和B淋巴细胞的再循环。相比之下，S1P（5）在大脑中检测到并调节少突胶质细胞的迁移和体外存活。在这里，我们显示S1P（5）在小鼠和人类的NK细胞中也表达，并且S1P（5）缺陷的小鼠在稳态条件下具有异常的NK细胞归巢。此外，我们发现S1P（5）是将NK细胞动员至发炎器官所必需的。我们的数据强调了调节各种淋巴细胞亚群循环的独特机制，并提高了通过专门针对S1P（5）的疗法操纵NK细胞贩运的可能性。

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