New tools for defining the 'genetic background' of inbred mouse strains

Ridgway WM; Healy B; Smink LJ; Rainbow D; Wicker LS

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New tools for defining the 'genetic background' of inbred mouse strains

机译：定义近交小鼠品系“遗传背景”的新工具

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There is general appreciation that `genetic background effects' can profoundly affect the immune phenotypes of congenic, transgenic and knockout mice. We suggest that attributing phenotypes to genetic background effects is outmoded and that new databases containing single-nucleotide polymorphisms obtained with a group of inbred mouse strains can be used to define the flanking DNA of nearly all mouse genes.

机译：人们普遍认识到“遗传背景效应”可以深刻影响同基因，转基因和基因敲除小鼠的免疫表型。我们建议将表型归因于遗传背景影响已过时，并且包含一组自交系小鼠品系获得的包含单核苷酸多态性的新数据库可用于定义几乎所有小鼠基因的侧翼DNA。

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《Nature immunology》 |2007年第7期|共5页
作者
Ridgway WM; Healy B; Smink LJ; Rainbow D; Wicker LS;
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原文格式 PDF
正文语种 eng
中图分类基础医学;
关键词
DIABETES RESEARCH; MICE; POLYMORPHISM; GENOME;

机译：糖尿病研究;小鼠;多态性;基因组;

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专利

1. New tools for defining the 'genetic background' of inbred mouse strains [J] . Ridgway WM, Healy B, Smink LJ, Nature immunology . 2007,第7期

机译：定义近交小鼠品系“遗传背景”的新工具
2. SKHIN/Sprd, a new genetically defined inbred hairless mouse strain for UV-induced skin carcinogenesis studies [J] . PerezC., Parker-ThornburgJ., MikulecC., Experimental dermatology . 2012,第3期

机译：SKHIN / Sprd，一种新的遗传定义的近交无毛小鼠品系，用于紫外线诱导的皮肤致癌研究
3. Assessment of learning by the Morris water task and fear conditioning in inbred mouse strains and F1 hybrids: implications of genetic background for single gene mutations and quantitative trait loci analyses. [J] . Owen EH, Logue SF, Rasmussen DL, Neuroscience: An International Journal under the Editorial Direction of IBRO . 1997,第4期

机译：自交小鼠品系和F1杂种的莫里斯水任务和恐惧条件的学习评估：遗传背景对单基因突变和数量性状基因座分析的影响。
4. Differences in bone brittleness between two genetically distinct inbred mouse strains [C] . Karl J.Jepsen, Teresa M.Pizzuto Bioengineering conference . 1999

机译：两种遗传上不同的近交小鼠品系的骨脆性差异
5. The genetic contribution to ingestive processes: An inbred mouse strain survey. [D] . Lewis-Levy, Sarah R. 2009

机译：遗传对食入过程的贡献：近交小鼠品系调查。
6. Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background [O] . Harry A Noyes, Morris Agaba, Susan Anderson, 2010

机译：对两个自交系小鼠品系和两个衍生的同系品系的基因型和表达分析表明大多数基因表达是反式调节的并且对遗传背景敏感
7. Genotype and expression analysis of two inbred mouse strains and two derived congenic strains suggest that most gene expression is trans regulated and sensitive to genetic background [O] . Hall Laurence, Gibson John, Brass Andy, 2010

机译：对两个自交系小鼠品系和两个衍生的同系品系的基因型和表达分析表明，大多数基因表达受 trans 调控且对遗传背景敏感

New tools for defining the 'genetic background' of inbred mouse strains

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