...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Nature immunology >Toll-like receptors: critical proteins linking innate and acquired immunity
【24h】

Toll-like receptors: critical proteins linking innate and acquired immunity

机译：Toll样受体：连接先天和后天免疫力的关键蛋白

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Recognition of pathogens is mediated by a set of germline-encoded receptors that are referred to as pattern-recognition receptors (PRRs). These receptors recognize conserved molecular patterns (pathogen-associated molecular patterns), which are shared by large groups of microorganisms. Toll-like receptors (TLRs) function as the PRRs in mammals and play an essential role in the recognition of microbial components. The TLRs may also recognize endogenous ligands induced during the inflammatory response. Similar cytoplasmic domains allow TLRs to use the same signaling molecules used by the interleukin I receptors (IL-IRs): these include MyD88, IL-IR-associated protein kinase and tumor necrosis factor receptor-activated factor 6. However, evidence is accumulating that the signaling pathways associated with each TLR are not identical and may, therefore, result in different biological responses.
机译：病原体的识别是由一组种系编码的受体介导的，这些受体被称为模式识别受体（PRR）。这些受体识别保守的分子模式（病原体相关的分子模式），这是由大量微生物共享的。 Toll样受体（TLR）在哺乳动物中起着PRR的作用，并且在识别微生物成分中起着至关重要的作用。 TLR还可以识别在炎症反应期间诱导的内源性配体。相似的胞质结构域允许TLR使用与白介素I受体（IL-IR）相同的信号分子：这些分子包括MyD88，IL-IR相关的蛋白激酶和肿瘤坏死因子受体激活因子6。但是，越来越多的证据表明，与每个TLR相关的信号通路并不相同，因此可能导致不同的生物学反应。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号