Mistaken notions about natural killer cells

Yokoyama WM

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Mistaken notions about natural killer cells

机译：关于自然杀伤细胞的错误观念

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As natural killer (NK) cells were first described more than 30 years ago-a lifetime in recent immunological history-this is a good time to reflect on their transition from outcasts of mainstream immunology to prominent players in innate immunity. Whereas much of our existing knowledge about NK cells is taken as longstanding fact, it may be surprising to immunologists of a younger vintage, particularly those working on NK cells today, that some of this knowledge was, at least initially, unexpected. In this Perspective, I take an unconventional approach to discussing our progress in understanding NK cells.

机译：由于自然杀伤（NK）细胞是在30多年前首次被描述的-在最近的免疫学史上一直存在-因此，这是反思其从主流免疫学的先驱者过渡到先天免疫的杰出参与者的好时机。尽管我们现有的有关NK细胞的许多知识都是长期存在的事实，但对于年轻一代的免疫学家（尤其是当今从事NK细胞研究的科学家）来说，这也许是令人惊讶的，但其中的某些知识至少在最初是始料未及的。在此观点中，我采用一种非常规的方法来讨论我们在了解NK细胞方面的进展。

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《Nature immunology》 |2008年第5期|共5页
作者
Yokoyama WM;
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正文语种 eng
中图分类基础医学;
关键词
MHC CLASS-I; LY-49 MULTIGENE FAMILY; C-TYPE LECTINS; NK CELLS; INHIBITORY RECEPTORS; CARBOHYDRATE-RECOGNITION; HLA-E; CD94; LIGAND; MOLECULES;

机译：MHC类别I;LY-49多基因家族;C型凝集素;NK细胞;抑制剂;碳水化合物识别;HLA-E;CD94;配体;分子;

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专利

1. Mistaken notions about natural killer cells [J] . Yokoyama WM Nature immunology . 2008,第5期

机译：关于自然杀伤细胞的错误观念
2. Intestinal T-cell and natural killer-cell lymphomas in Taiwan with special emphasis on 2 distinct cellular types: natural killer-like cytotoxic T cell and true natural killer cell. [J] . Tung CL, Hsieh PP, Chang JH, Human Pathology . 2008,第7期

机译：台湾的肠道T细胞和自然杀伤细胞淋巴瘤特别着重于两种不同的细胞类型：类自然杀伤细胞毒性T细胞和真正的自然杀伤细胞。
3. Ex vivo generated natural killer cells acquire typical natural killer receptors and display a cytotoxic gene expression profile similar to peripheral blood natural killer cells [J] . LehmannD., SpanholtzJ., OslM., Stem cells and development . 2012,第16期

机译：离体产生的自然杀伤细胞获得典型的自然杀伤受体，并显示类似于外周血自然杀伤细胞的细胞毒性基因表达谱
4. Unnatural killer cells: TRAIL-coated leukocytes that kill cancer cells in the circulation [C] . Mitchell M.J., Wayne E.C., Rana K., 2014 40th Annual Northeast Bioengineering Conference . 2014

机译：非自然杀伤细胞：TRAIL涂层的白细胞可杀死循环中的癌细胞
5. Identification and characterization of the production of chemokines by natural killer cells and investigations into the effects of these cytokines on natural killer cell biology. [D] . Bluman, Eric Michael. 1998

机译：鉴定和表征自然杀伤细胞产生的趋化因子，并研究这些细胞因子对自然杀伤细胞生物学的影响。
6. Ex Vivo Generated Natural Killer Cells Acquire Typical Natural Killer Receptors and Display a Cytotoxic Gene Expression Profile Similar to Peripheral Blood Natural Killer Cells [O] . Dorit Lehmann, Jan Spanholtz, Markus Osl, -1

机译：体内生成的自然杀伤细胞获得典型的自然杀伤受体并显示类似于外周血自然杀伤细胞的细胞毒性基因表达谱
7. Ex Vivo Generated Natural Killer Cells Acquire Typical Natural Killer Receptors and Display a Cytotoxic Gene Expression Profile Similar to Peripheral Blood Natural Killer Cells [O] . Dorit Lehmann, Jan Spanholtz, Markus Osl, 2012

机译：exvivo产生的天然杀手细胞获得典型的自然杀伤受体，并显示与外周血自然杀伤细胞相似的细胞毒性基因表达谱

Mistaken notions about natural killer cells

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