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首页> 外文期刊>Nature immunology >The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.
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The cytosolic nucleic acid sensor LRRFIP1 mediates the production of type I interferon via a beta-catenin-dependent pathway.

机译：胞质核酸传感器LRRFIP1通过β-catenin依赖性途径介导I型干扰素的产生。

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摘要

Intracellular nucleic acid sensors detect microbial RNA and DNA and trigger the production of type I interferon. However, the cytosolic nucleic acid-sensing system remains to be fully identified. Here we show that the cytosolic nucleic acid-binding protein LRRFIP1 contributed to the production of interferon-beta (IFN-beta) induced by vesicular stomatitis virus (VSV) and Listeria monocytogenes in macrophages. LRRFIP1 bound exogenous nucleic acids and increased the expression of IFN-beta induced by both double-stranded RNA and double-stranded DNA. LRRFIP1 interacted with beta-catenin and promoted the activation of beta-catenin, which increased IFN-beta expression by binding to the C-terminal domain of the transcription factor IRF3 and recruiting the acetyltransferase p300 to the IFN-beta enhanceosome via IRF3. Therefore, LRRFIP1 and its downstream partner beta-catenin constitute another coactivator pathway for IRF3-mediated production of type I interferon.
机译：细胞内核酸传感器检测微生物RNA和DNA，并触发I型干扰素的产生。然而，胞质核酸传感系统仍有待完全鉴定。在这里，我们显示了胞质核酸结合蛋白LRRFIP1有助于水泡性口炎病毒（VSV）和单核细胞增生性李斯特菌在巨噬细胞中诱导产生干扰素-β（IFN-β）。 LRRFIP1绑定外源核酸，并增加了双链RNA和双链DNA诱导的IFN-β的表达。 LRRFIP1与β-catenin相互作用并促进β-catenin的活化，从而通过与转录因子IRF3的C末端结构域结合并通过IRF3将乙酰转移酶p300募集到IFN-β增强体来增加IFN-β的表达。因此，LRRFIP1及其下游伙伴β-连环蛋白构成IRF3介导的I型干扰素生产的另一种共激活因子途径。

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