Molecular definition of the identity and activation of natural killer cells

BezmanN.A.; KimC.C.; SunJ.C.; Min-OoG.; HendricksD.W.; KamimuraY.; BestJ.A.; GoldrathA.W.; LanierL.L.; GautierE.L.; JakubzickC.; RandolphG.J.; BestA.J.; KnellJ.; MillerJ.; BrownB.; MeradM.; JojicV.; KollerD.; CohenN.; BrennanP.; BrennerM.; ShayT.; RegevA.; FletcherA.; ElpekK.; Bellemare-PelletierA.; MalhotraD.; TurleyS.; JianuR.; LaidlawD.; CollinsJ.J.; NarayanK.; SylviaK.; KangJ.; GazitR.; RossiD.J.; KimF.; RaoT.N.; WagersA.; ShintonS.A.; HardyR.R.; MonachP.; HengT.; KreslavskyT.; PainterM.; EricsonJ.; DavisS.; MathisD.; BenoistC.

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Molecular definition of the identity and activation of natural killer cells

机译：天然杀伤细胞身份和激活的分子定义

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Using whole-genome microarray data sets of the Immunological Genome Project, we demonstrate a closer transcriptional relationship between NK cells and T cells than between any other leukocytes, distinguished by their shared expression of genes encoding molecules with similar signaling functions. Whereas resting NK cells are known to share expression of a few genes with cytotoxic CD8 + T cells, our transcriptome-wide analysis demonstrates that the commonalities extend to hundreds of genes, many encoding molecules with unknown functions. Resting NK cells demonstrate a 'preprimed' state compared with naive T cells, which allows NK cells to respond more rapidly to viral infection. Collectively, our data provide a global context for known and previously unknown molecular aspects of NK cell identity and function by delineating the genome-wide repertoire of gene expression of NK cells in various states.

机译：使用免疫基因组计划的全基因组微阵列数据集，我们证明了NK细胞和T细胞之间比任何其他白细胞之间更紧密的转录关系，区别在于它们共享编码具有相似信号功能的分子的基因。已知静止的NK细胞与细胞毒性CD8 + T细胞共享一些基因的表达，而我们在转录组范围内的分析表明，共有性扩展到数百种基因，许多编码分子的功能未知。与幼稚的T细胞相比，静止的NK细胞表现出“预致敏”状态，从而使NK细胞对病毒感染的反应更快。总体而言，我们的数据通过描绘各种状态下NK细胞基因表达的全基因组范围，为NK细胞身份和功能的已知和先前未知的分子方面提供了一个整体背景。

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《Nature immunology》 |2012年第10期|共9页
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BezmanN.A.; KimC.C.; SunJ.C.; Min-OoG.; HendricksD.W.; KamimuraY.; BestJ.A.; GoldrathA.W.; LanierL.L.; GautierE.L.; JakubzickC.; RandolphG.J.; BestA.J.; KnellJ.; MillerJ.; BrownB.; MeradM.; JojicV.; KollerD.; CohenN.; BrennanP.; BrennerM.; ShayT.; RegevA.; FletcherA.; ElpekK.; Bellemare-PelletierA.; MalhotraD.; TurleyS.; JianuR.; LaidlawD.; CollinsJ.J.; NarayanK.; SylviaK.; KangJ.; GazitR.; RossiD.J.; KimF.; RaoT.N.; WagersA.; ShintonS.A.; HardyR.R.; MonachP.; HengT.; KreslavskyT.; PainterM.; EricsonJ.; DavisS.; MathisD.; BenoistC.;
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1. Molecular definition of the identity and activation of natural killer cells [J] . BezmanN.A., KimC.C., SunJ.C., Nature immunology . 2012,第10期

机译：天然杀伤细胞身份和激活的分子定义
2. Molecular mechanisms of natural killer cell activation in response to cellular stress [J] . ChanC.J., SmythM.J., MartinetL. Cell death and differentiation . 2014,第1期

机译：天然杀伤细胞活化响应细胞应激的分子机制
3. Genome wide transcriptional analysis of resting and IL2 activated human natural killer cells: gene expression signatures indicative of novel molecular signaling pathways [J] . Karen Dybkaer, Javeed Iqbal, Guimei Zhou, BMC Genomics . 2007,第1期

机译：静止和IL2激活的人类自然杀伤细胞的全基因组转录分析：指示新型分子信号通路的基因表达特征
4. Imaging Lung Clearance of Radio labeled Tumor Cells to Study Mice with Normal, Activated or Depleted Natural Killer (NK) Cells [C] . P.V. Kulkarni, M. Bennett, A. Constantinescu, Application of Accelerators in Research and Industry . 2003

机译：对放射性标记的肿瘤细胞的肺间隙进行成像，以研究具有正常，活化或耗尽的自然杀伤（NK）细胞的小鼠
5. CD16xCD33 bispecific killer cell engager (BiKE) activates natural killer (NK) cells from myelodysplastic syndrome (MDS) patients against primary MDS and myeloidderived suppressor cell (MDSC) CD33-positive targets. [D] . Gleason, Michelle K. 2014

机译：CD16xCD33双特异性杀伤细胞接合剂（BiKE）激活来自骨髓增生异常综合征（MDS）患者的自然杀伤（NK）细胞，以抵抗原发性MDS和髓样抑制细胞（MDSC）CD33阳性靶标。
6. ImmGen Report: Molecular definition of Natural Killer cell identity and activation [O] . Natalie A. Bezman, Charles C. Kim, Joseph C. Sun, -1

机译：ImmGen报告：自然杀伤细胞的身份和活化的分子定义
7. Molecular definition of the identity and activation of natural killer cells [O] . Bezman, Natalie A., Kim, Charles C., Sun, Joseph C., 2012

机译：自然杀伤细胞的身份和活化的分子定义

Molecular definition of the identity and activation of natural killer cells

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